Evaluation of the Effects of Intravenous Lipid Emulsion Administration on Coagulation Parameters in Healthy Dogs
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2026
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| author | Sarah M. Hayes Kristen Marshall Rebecca E. Bergee Julie C. Schildt |
| author_facet | Sarah M. Hayes Kristen Marshall Rebecca E. Bergee Julie C. Schildt Sarah M. Hayes Kristen Marshall Rebecca E. Bergee Julie C. Schildt |
| collection | Wiley Open Access |
| contents | Evaluation of the Effects of Intravenous Lipid Emulsion Administration on Coagulation Parameters in Healthy Dogs Sarah M. Hayes Kristen Marshall Rebecca E. Bergee Julie C. Schildt Journal of Veterinary Emergency and Critical Care ABSTRACT Objective To determine if the administration of 20% intravenous lipid emulsion (ILE) to healthy dogs at the standard antidotal dose induces a hypocoagulable state. Design Prospective, nonblinded, crossover study. Setting University teaching hospital. Animals Twelve adult, purpose‐bred Beagles with no history of recent illness or underlying endocrine disease. Interventions Treated dogs received 20% ILE using a standard protocol for management of intoxications: 2 mL/kg bolus over 2 min, followed by 0.25 mL/kg/min for 60 min. Control dogs received lactated Ringer's solution (LRS) using the same dosing scheme. Dogs were randomly assigned to receive ILE or LRS, then received the alternate treatment after a 1‐week washout period. Measurements and Main Results Viscoelastic coagulation monitoring parameters using a benchtop viscoelastic coagulation monitor, prothrombin time (PT), activated partial thromboplastic time, and platelet count were measured 5 min before and 5 min after interventions. Compared with LRS administration, there was an increase in clot formation time after ILE administration and a decrease in the alpha angle, amplitude at 10 min, and amplitude at 20 min. There was an increase in PT after LRS infusion. Otherwise, no differences were noted in PT, activated partial thromboplastic time, platelet counts, or remaining viscoelastic coagulation monitoring parameters for either group. Conclusions Viscoelastic findings were suggestive of a relative hypocoagulability after ILE administration. Although statistically significant, most of these values were still within the provided reference intervals, so the magnitude of change may not be clinically important. The increase in PT after LRS solution, while statistically significant, was clinically irrelevant. ILE was well tolerated at the antidotal dose and did not have a clinically relevant effect on coagulation in otherwise healthy dogs in this study. 10.1111/vec.70099 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/vec.70099 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_vec_70099 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Evaluation of the Effects of Intravenous Lipid Emulsion Administration on Coagulation Parameters in Healthy Dogs Sarah M. Hayes Kristen Marshall Rebecca E. Bergee Julie C. Schildt Journal of Veterinary Emergency and Critical Care Evaluation of the Effects of Intravenous Lipid Emulsion Administration on Coagulation Parameters in Healthy Dogs Sarah M. Hayes Kristen Marshall Rebecca E. Bergee Julie C. Schildt Journal of Veterinary Emergency and Critical Care ABSTRACT Objective To determine if the administration of 20% intravenous lipid emulsion (ILE) to healthy dogs at the standard antidotal dose induces a hypocoagulable state. Design Prospective, nonblinded, crossover study. Setting University teaching hospital. Animals Twelve adult, purpose‐bred Beagles with no history of recent illness or underlying endocrine disease. Interventions Treated dogs received 20% ILE using a standard protocol for management of intoxications: 2 mL/kg bolus over 2 min, followed by 0.25 mL/kg/min for 60 min. Control dogs received lactated Ringer's solution (LRS) using the same dosing scheme. Dogs were randomly assigned to receive ILE or LRS, then received the alternate treatment after a 1‐week washout period. Measurements and Main Results Viscoelastic coagulation monitoring parameters using a benchtop viscoelastic coagulation monitor, prothrombin time (PT), activated partial thromboplastic time, and platelet count were measured 5 min before and 5 min after interventions. Compared with LRS administration, there was an increase in clot formation time after ILE administration and a decrease in the alpha angle, amplitude at 10 min, and amplitude at 20 min. There was an increase in PT after LRS infusion. Otherwise, no differences were noted in PT, activated partial thromboplastic time, platelet counts, or remaining viscoelastic coagulation monitoring parameters for either group. Conclusions Viscoelastic findings were suggestive of a relative hypocoagulability after ILE administration. Although statistically significant, most of these values were still within the provided reference intervals, so the magnitude of change may not be clinically important. The increase in PT after LRS solution, while statistically significant, was clinically irrelevant. ILE was well tolerated at the antidotal dose and did not have a clinically relevant effect on coagulation in otherwise healthy dogs in this study. 10.1111/vec.70099 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Evaluation of the Effects of Intravenous Lipid Emulsion Administration on Coagulation Parameters in Healthy Dogs |
| topic | Journal of Veterinary Emergency and Critical Care |
| url | https://onlinelibrary.wiley.com/doi/10.1111/vec.70099 |