Fibroblast growth factor homologous factors: canonical and non‐canonical mechanisms of action
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Wiley Open Access
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| Natura: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867011991483187201 |
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| author | Mitchell Goldfarb |
| author_facet | Mitchell Goldfarb Mitchell Goldfarb |
| collection | Wiley Open Access |
| contents | Fibroblast growth factor homologous factors: canonical and non‐canonical mechanisms of action Mitchell Goldfarb The Journal of Physiology AbstractSince their discovery nearly 30 years ago, fibroblast growth factor homologous factors (FHFs) are now known to control the functionality of excitable tissues through a range of mechanisms. Nervous and cardiac system dysfunctions are caused by loss‐ or gain‐of‐function mutations in FHF genes. The best understood ‘canonical’ targets for FHF action are voltage‐gated sodium channels, and recent studies have expanded the repertoire of ways that FHFs modulate sodium channel gating. Additional ‘non‐canonical’ functions of FHFs in excitable and non‐excitable cells, including cancer cells, have been reported over the past dozen years. This review summarizes and evaluates reported canonical and non‐canonical FHF functions. image 10.1113/jp286313 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1113/jp286313 |
| format | Artículo Open Access |
| id | wiley_oa_10_1113_jp286313 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Fibroblast growth factor homologous factors: canonical and non‐canonical mechanisms of action Mitchell Goldfarb The Journal of Physiology Fibroblast growth factor homologous factors: canonical and non‐canonical mechanisms of action Mitchell Goldfarb The Journal of Physiology AbstractSince their discovery nearly 30 years ago, fibroblast growth factor homologous factors (FHFs) are now known to control the functionality of excitable tissues through a range of mechanisms. Nervous and cardiac system dysfunctions are caused by loss‐ or gain‐of‐function mutations in FHF genes. The best understood ‘canonical’ targets for FHF action are voltage‐gated sodium channels, and recent studies have expanded the repertoire of ways that FHFs modulate sodium channel gating. Additional ‘non‐canonical’ functions of FHFs in excitable and non‐excitable cells, including cancer cells, have been reported over the past dozen years. This review summarizes and evaluates reported canonical and non‐canonical FHF functions. image 10.1113/jp286313 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Fibroblast growth factor homologous factors: canonical and non‐canonical mechanisms of action |
| topic | The Journal of Physiology |
| url | https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP286313 |