Sustainable Synthesis of Cu/SeO 2 and Co/SeO 2 Nanocomposites Using Rosmarinus officinalis Leaf Extract: Characterization, Phytochemical Analysis, Antioxidant, and Antibacterial Activities
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2025
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| _version_ | 1867013837848313856 |
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| author | Fatima B. Alamri |
| author_facet | Fatima B. Alamri Fatima B. Alamri |
| collection | Wiley Open Access |
| contents | Sustainable Synthesis of Cu/SeO 2 and Co/SeO 2 Nanocomposites Using Rosmarinus officinalis Leaf Extract: Characterization, Phytochemical Analysis, Antioxidant, and Antibacterial Activities Fatima B. Alamri Journal of Nanotechnology The novel global issue of antimicrobial resistance (AMR) and oxidative stress necessitates sustainable and creative solutions. This study presents the green synthesis of Cu/SeO 2 and Co/SeO 2 nanocomposites using Rosmarinus officinalis (rosemary) leaf extract as a natural reducing and stabilizing agent. The nanocomposites were characterized by UV‐visible, FTIR, XRD, SEM, HR‐TEM, zeta potential, DLS, and EDX to verify their structural, morphological, and compositional features. Phytochemical analysis of the rosemary extract revealed its richness in phytochemical content, which facilitated the synthesis and stabilization of the nanocomposites. The antioxidant activity of the nanocomposites was studied by DPPH and ferric‐reducing power assays, demonstrating significant free radical scavenging capacity. Additionally, the antibacterial activity was appraised against both Gram‐negative and Gram‐positive pathogenic bacterial strains by a well diffusion assay. It was found that R. officinalis extract showed no activity, but Cu/SeO 2 and Co/SeO 2 NCs demonstrated privileged antibacterial activities. Co/SeO 2 NC exhibited the best performance with inhibition zones of 44.0 ± 1.27 mm against E. coli , 40.0 ± 1.34 mm against K. pneumoniae , and 43.0 ± 1.49 mm against E. Cloacae , compared with Cu/SeO 2 NCs and gentamycin. The synergistic features of copper, cobalt, and selenium within the nanocomposites highlight their potential as dual‐action agents for mitigating oxidative stress and bacterial infections. This study underscores the potential of green‐synthesized Cu/SeO 2 and Co/SeO 2 nanocomposites as eco‐friendly and biocompatible alternatives for biomedical and environmental applications. 10.1155/jnt/1027481 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1155/jnt/1027481 |
| format | Artículo Open Access |
| id | wiley_oa_10_1155_jnt_1027481 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Sustainable Synthesis of Cu/SeO 2 and Co/SeO 2 Nanocomposites Using Rosmarinus officinalis Leaf Extract: Characterization, Phytochemical Analysis, Antioxidant, and Antibacterial Activities Fatima B. Alamri Journal of Nanotechnology Sustainable Synthesis of Cu/SeO 2 and Co/SeO 2 Nanocomposites Using Rosmarinus officinalis Leaf Extract: Characterization, Phytochemical Analysis, Antioxidant, and Antibacterial Activities Fatima B. Alamri Journal of Nanotechnology The novel global issue of antimicrobial resistance (AMR) and oxidative stress necessitates sustainable and creative solutions. This study presents the green synthesis of Cu/SeO 2 and Co/SeO 2 nanocomposites using Rosmarinus officinalis (rosemary) leaf extract as a natural reducing and stabilizing agent. The nanocomposites were characterized by UV‐visible, FTIR, XRD, SEM, HR‐TEM, zeta potential, DLS, and EDX to verify their structural, morphological, and compositional features. Phytochemical analysis of the rosemary extract revealed its richness in phytochemical content, which facilitated the synthesis and stabilization of the nanocomposites. The antioxidant activity of the nanocomposites was studied by DPPH and ferric‐reducing power assays, demonstrating significant free radical scavenging capacity. Additionally, the antibacterial activity was appraised against both Gram‐negative and Gram‐positive pathogenic bacterial strains by a well diffusion assay. It was found that R. officinalis extract showed no activity, but Cu/SeO 2 and Co/SeO 2 NCs demonstrated privileged antibacterial activities. Co/SeO 2 NC exhibited the best performance with inhibition zones of 44.0 ± 1.27 mm against E. coli , 40.0 ± 1.34 mm against K. pneumoniae , and 43.0 ± 1.49 mm against E. Cloacae , compared with Cu/SeO 2 NCs and gentamycin. The synergistic features of copper, cobalt, and selenium within the nanocomposites highlight their potential as dual‐action agents for mitigating oxidative stress and bacterial infections. This study underscores the potential of green‐synthesized Cu/SeO 2 and Co/SeO 2 nanocomposites as eco‐friendly and biocompatible alternatives for biomedical and environmental applications. 10.1155/jnt/1027481 http://creativecommons.org/licenses/by/4.0/ |
| title | Sustainable Synthesis of Cu/SeO 2 and Co/SeO 2 Nanocomposites Using Rosmarinus officinalis Leaf Extract: Characterization, Phytochemical Analysis, Antioxidant, and Antibacterial Activities |
| topic | Journal of Nanotechnology |
| url | https://onlinelibrary.wiley.com/doi/10.1155/jnt/1027481 |