Differential rewarding effects of electrical stimulation of the lateral hypothalamus and parabrachial complex: Functional characterization and the relevance of opioid systems and dopamine
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2019
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| _version_ | 1866901914820542464 |
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| author | Simon, Maria J. Zafra, Maria Angeles Puerto, Amadeo |
| author_facet | Simon, Maria J. Zafra, Maria Angeles Puerto, Amadeo |
| contents | <p>Background: Since the discovery of rewarding intracranial self-stimulation by Olds and Milner, extensive data have been published on the biological<br>basis of reward. Although participation of the mesolimbic dopaminergic system is well documented, its precise role has not been fully elucidated, and<br>some authors have proposed the involvement of other neural systems in processing specific aspects of reinforced behaviour.<br>Aims and methods: We reviewed published data, including our own findings, on the rewarding effects induced by electrical stimulation of the lateral<br>hypothalamus (LH) and of the external lateral parabrachial area (LPBe) – a brainstem region involved in processing the rewarding properties of natural<br>and artificial substances – and compared its functional characteristics as observed in operant and non-operant behavioural procedures.<br>Results: Brain circuits involved in the induction of preferences for stimuli associated with electrical stimulation of the LBPe appear to functionally<br>and neurochemically differ from those activated by electrical stimulation of the LH.<br>Interpretation: We discuss the possible involvement of the LPBe in processing emotional-affective aspects of the brain reward system.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_1177_0269881119855982 |
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| publishDate | 2019 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Differential rewarding effects of electrical stimulation of the lateral hypothalamus and parabrachial complex: Functional characterization and the relevance of opioid systems and dopamine Simon, Maria J. Zafra, Maria Angeles Puerto, Amadeo Motivation, reward, lateral hypothalamus (LH), external lateral parabrachial nucleus (LPBe), opioids, dopamine <p>Background: Since the discovery of rewarding intracranial self-stimulation by Olds and Milner, extensive data have been published on the biological<br>basis of reward. Although participation of the mesolimbic dopaminergic system is well documented, its precise role has not been fully elucidated, and<br>some authors have proposed the involvement of other neural systems in processing specific aspects of reinforced behaviour.<br>Aims and methods: We reviewed published data, including our own findings, on the rewarding effects induced by electrical stimulation of the lateral<br>hypothalamus (LH) and of the external lateral parabrachial area (LPBe) – a brainstem region involved in processing the rewarding properties of natural<br>and artificial substances – and compared its functional characteristics as observed in operant and non-operant behavioural procedures.<br>Results: Brain circuits involved in the induction of preferences for stimuli associated with electrical stimulation of the LBPe appear to functionally<br>and neurochemically differ from those activated by electrical stimulation of the LH.<br>Interpretation: We discuss the possible involvement of the LPBe in processing emotional-affective aspects of the brain reward system.</p> |
| title | Differential rewarding effects of electrical stimulation of the lateral hypothalamus and parabrachial complex: Functional characterization and the relevance of opioid systems and dopamine |
| topic | Motivation, reward, lateral hypothalamus (LH), external lateral parabrachial nucleus (LPBe), opioids, dopamine |
| url | https://doi.org/10.1177/0269881119855982 |