Impact of anemia on the association between red cell distribution width and 1-year mortality in acute heart failure patients
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2026
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| author | Maita-Arauco, Sherelym Alessandra Quispe-Vasquez, Sthephanie María Benites-Zapata, Vicente Aleixandre Segura-Saldaña, Pedro Antonio |
| author_facet | Maita-Arauco, Sherelym Alessandra Quispe-Vasquez, Sthephanie María Benites-Zapata, Vicente Aleixandre Segura-Saldaña, Pedro Antonio |
| contents | <p>Background: Different accessible and low-cost biomarkers have been investigated to stratify patients with acute heart failure (AHF). One of them is the red cell distribution width (RDW), which proved to be a greater prognostic marker of mortality than other conventional markers. Objective: Therefore, the objective of our study is to determine whether the anemic status modifies the magnitude of association between high RDW and 1-year mortality in patients with AHF. Design: Observational, analytical, retrospective cohort study. Methods: We included participants ⩾18 years old hospitalized with a diagnosis of AHF. As an association measure, a crude and adjusted generalized linear model of the Poisson family calculated the risk ratio (RR) with a 95% confidence interval (95% CI). Results: In all, 709 participants with an average age of 73.48 years were included. At 1 year, the risk of dying was three times higher with high RDW (RR = 3.05, 95% CI: 1.39–6.66; p < 0.01). In anemic participants, the risk of dying at 1 year is two times greater with high RDW (RR = 2.18, 95% CI: 0.91–5.22; p = 0.07), while in non-anemic participants, the risk of dying increased almost seven times (RR = 6.95, 95% CI: 1.65–29.23; p < 0.01). Conclusion: High RDW is a risk factor for mortality at 1 year in patients with AHF. A greater magnitude of association was found in non-anemic patients. © The Author(s), 2025.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_1177_17539447251366798 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Impact of anemia on the association between red cell distribution width and 1-year mortality in acute heart failure patients Maita-Arauco, Sherelym Alessandra Quispe-Vasquez, Sthephanie María Benites-Zapata, Vicente Aleixandre Segura-Saldaña, Pedro Antonio acute heart failure anemia mortality red cell distribution width <p>Background: Different accessible and low-cost biomarkers have been investigated to stratify patients with acute heart failure (AHF). One of them is the red cell distribution width (RDW), which proved to be a greater prognostic marker of mortality than other conventional markers. Objective: Therefore, the objective of our study is to determine whether the anemic status modifies the magnitude of association between high RDW and 1-year mortality in patients with AHF. Design: Observational, analytical, retrospective cohort study. Methods: We included participants ⩾18 years old hospitalized with a diagnosis of AHF. As an association measure, a crude and adjusted generalized linear model of the Poisson family calculated the risk ratio (RR) with a 95% confidence interval (95% CI). Results: In all, 709 participants with an average age of 73.48 years were included. At 1 year, the risk of dying was three times higher with high RDW (RR = 3.05, 95% CI: 1.39–6.66; p < 0.01). In anemic participants, the risk of dying at 1 year is two times greater with high RDW (RR = 2.18, 95% CI: 0.91–5.22; p = 0.07), while in non-anemic participants, the risk of dying increased almost seven times (RR = 6.95, 95% CI: 1.65–29.23; p < 0.01). Conclusion: High RDW is a risk factor for mortality at 1 year in patients with AHF. A greater magnitude of association was found in non-anemic patients. © The Author(s), 2025.</p> |
| title | Impact of anemia on the association between red cell distribution width and 1-year mortality in acute heart failure patients |
| topic | acute heart failure anemia mortality red cell distribution width |
| url | https://doi.org/10.1177/17539447251366798 |