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| Format: | Recurso digital |
| Langue: | anglais |
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Zenodo
2026
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| Accès en ligne: | https://doi.org/10.1186/s41747-025-00663-1 |
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| _version_ | 1866902172961079296 |
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| author | Jimenez-Pastor, A Marti-Aguado, D Pereira, B Alfaro-Cervello, C Perez-Girbes, A Alberich-Bayarri, A Marti-Bonmati, L |
| author_facet | Jimenez-Pastor, A Marti-Aguado, D Pereira, B Alfaro-Cervello, C Perez-Girbes, A Alberich-Bayarri, A Marti-Bonmati, L |
| contents | ObjectivesThis study investigated the influence of hepatic vessels on the quantification of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) and R2* using automated whole-liver segmentation.Materials and methodsThis prospective multicenter study included patients with chronic liver disease having paired liver biopsy and MR exams with a standardized multiecho chemical-shift gradient echo sequence. Automated whole-liver segmentation was performed, generating two masks per patient, one including and the other excluding the major hepatic vessels. PDFF and R2* were quantified and graded for both masks. Histological grading of hepatic steatosis and iron overload severity was used as a reference standard.ResultsA total of 377 patients were evaluated, of whom 54% had hepatic steatosis and 20% had iron overload on biopsy readings. Stratified by histological grades, there were no statistically significant differences in the distribution of PDFF or R2* between the two segmentation masks. Overall, PDFF and R2* values were minimally lower when vessels were included, with a bias of -0.06% for PDFF and -0.25 s-1 for R2*. A lower coefficient of variation was obtained for both imaging parameters after excluding vessels. Patients were classified in the same PDFF grades despite the segmentation approach, and only 7 cases (1.9% of the study population) were reclassified for R2* grading, all being upgraded after vessel exclusion.ConclusionExcluding hepatic vessels entails nonsignificant differences in PDFF and R2* quantification. Although with limited impact, vessel exclusion improves biomarker precision in research settings demanding high accuracy and increases clinicians' confidence when using automatic tools in clinical practice.Relevance statementFat and iron quantification on MRI are key imaging biomarkers for the accurate non-invasive assessment of patients with chronic liver disease. Proton density, fat fraction, and R2* quantification show minimal differences if hepatic vessels are included or excluded from the liver segmentation mask.Key PointsThe effect of hepatic vessels on proton density, fat fraction, and R2* quantification was evaluated.No significant differences were found, excluding hepatic vessels, although their inclusion showed a small negative bias.Vessel exclusion may improve clinicians' confidence and precision in high-sensitivity applications. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_1186_s41747-025-00663-1 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Impact of hepatic vessels on whole liver proton density fat fraction and R2*quantification Jimenez-Pastor, A Marti-Aguado, D Pereira, B Alfaro-Cervello, C Perez-Girbes, A Alberich-Bayarri, A Marti-Bonmati, L adolescent adult aged Article body mass chronic liver disease clinical practice cohort analysis fat mass female histology human human tissue image analysis image quality liver biopsy liver blood vessel major clinical study male multicenter study nuclear magnetic resonance imaging prospective study R2 quantification T2 weighted imaging whole liver proton density fat fraction biopsy clinical trial diagnostic imaging fatty liver liver middle aged pathology procedures vascularization proton Adult Aged Biopsy Fatty Liver Female Humans Liver Magnetic Resonance Imaging Male Middle Aged Prospective Studies Protons ObjectivesThis study investigated the influence of hepatic vessels on the quantification of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) and R2* using automated whole-liver segmentation.Materials and methodsThis prospective multicenter study included patients with chronic liver disease having paired liver biopsy and MR exams with a standardized multiecho chemical-shift gradient echo sequence. Automated whole-liver segmentation was performed, generating two masks per patient, one including and the other excluding the major hepatic vessels. PDFF and R2* were quantified and graded for both masks. Histological grading of hepatic steatosis and iron overload severity was used as a reference standard.ResultsA total of 377 patients were evaluated, of whom 54% had hepatic steatosis and 20% had iron overload on biopsy readings. Stratified by histological grades, there were no statistically significant differences in the distribution of PDFF or R2* between the two segmentation masks. Overall, PDFF and R2* values were minimally lower when vessels were included, with a bias of -0.06% for PDFF and -0.25 s-1 for R2*. A lower coefficient of variation was obtained for both imaging parameters after excluding vessels. Patients were classified in the same PDFF grades despite the segmentation approach, and only 7 cases (1.9% of the study population) were reclassified for R2* grading, all being upgraded after vessel exclusion.ConclusionExcluding hepatic vessels entails nonsignificant differences in PDFF and R2* quantification. Although with limited impact, vessel exclusion improves biomarker precision in research settings demanding high accuracy and increases clinicians' confidence when using automatic tools in clinical practice.Relevance statementFat and iron quantification on MRI are key imaging biomarkers for the accurate non-invasive assessment of patients with chronic liver disease. Proton density, fat fraction, and R2* quantification show minimal differences if hepatic vessels are included or excluded from the liver segmentation mask.Key PointsThe effect of hepatic vessels on proton density, fat fraction, and R2* quantification was evaluated.No significant differences were found, excluding hepatic vessels, although their inclusion showed a small negative bias.Vessel exclusion may improve clinicians' confidence and precision in high-sensitivity applications. |
| title | Impact of hepatic vessels on whole liver proton density fat fraction and R2*quantification |
| topic | adolescent adult aged Article body mass chronic liver disease clinical practice cohort analysis fat mass female histology human human tissue image analysis image quality liver biopsy liver blood vessel major clinical study male multicenter study nuclear magnetic resonance imaging prospective study R2 quantification T2 weighted imaging whole liver proton density fat fraction biopsy clinical trial diagnostic imaging fatty liver liver middle aged pathology procedures vascularization proton Adult Aged Biopsy Fatty Liver Female Humans Liver Magnetic Resonance Imaging Male Middle Aged Prospective Studies Protons |
| url | https://doi.org/10.1186/s41747-025-00663-1 |