| _version_ | 1866901131229134848 |
|---|---|
| author | Picone, Pasquale Sanfilippo, Tiziana Vasto, Sonya Baldassano, Sara Guggino, Rossella Nuzzo, Domenico Bulone, Donatella San Biagio, Pier Luigi Muscolino, Emanuela Monastero, Roberto Dispenza, Clelia Giacomazza, Daniela |
| author_facet | Picone, Pasquale Sanfilippo, Tiziana Vasto, Sonya Baldassano, Sara Guggino, Rossella Nuzzo, Domenico Bulone, Donatella San Biagio, Pier Luigi Muscolino, Emanuela Monastero, Roberto Dispenza, Clelia Giacomazza, Daniela |
| contents | <p>Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly. The two cardinal neuropathological hallmarks of AD are the senile plaques, which are extracellular deposits mainly constituted by beta-amyloids, and neurofibrillary tangles formed by abnormally phosphorylated Tau (p-Tau) located in the cytoplasm of neurons. Although the research has made relevant progress in the management of the disease, the treatment is still lacking. Only symptomatic medications exist for the disease, and, in the meantime, laboratories worldwide are investigating disease-modifying treatments for AD. In the present review, results centered on the use of peptides of different sizes involved in AD are presented.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_3390_biom12101344 |
| institution | Zenodo |
| language | |
| publishDate | 2022 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | From Small Peptides to Large Proteins against Alzheimer's Disease Picone, Pasquale Sanfilippo, Tiziana Vasto, Sonya Baldassano, Sara Guggino, Rossella Nuzzo, Domenico Bulone, Donatella San Biagio, Pier Luigi Muscolino, Emanuela Monastero, Roberto Dispenza, Clelia Giacomazza, Daniela Alzheimer's disease; Tau protein; neurofibrillary tangles; amyloid-beta protein: amyloid fibrillation <p>Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly. The two cardinal neuropathological hallmarks of AD are the senile plaques, which are extracellular deposits mainly constituted by beta-amyloids, and neurofibrillary tangles formed by abnormally phosphorylated Tau (p-Tau) located in the cytoplasm of neurons. Although the research has made relevant progress in the management of the disease, the treatment is still lacking. Only symptomatic medications exist for the disease, and, in the meantime, laboratories worldwide are investigating disease-modifying treatments for AD. In the present review, results centered on the use of peptides of different sizes involved in AD are presented.</p> |
| title | From Small Peptides to Large Proteins against Alzheimer's Disease |
| topic | Alzheimer's disease; Tau protein; neurofibrillary tangles; amyloid-beta protein: amyloid fibrillation |
| url | https://doi.org/10.3390/biom12101344 |