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Zenodo
2023
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| Accès en ligne: | https://doi.org/10.5281/zenodo.10019493 |
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| _version_ | 1866902109685809152 |
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| author | Bhukya Madhulatha , Zeenath Ruhy |
| author_facet | Bhukya Madhulatha , Zeenath Ruhy |
| contents | <p><i>The objective of the present study was to prepare and evaluate the mucoadhesive microspheres of Febuxostat. Febuxostat microspheres were prepared by ionotropic gelation method using polymers such as HPMC (K 100 M), Carbopol 940P, sodium CMC, sodium alginate, ethyl cellulose, methyl cellulose. Totally 12 different formulations of Febuxostat were prepared by using the above polymers. The microspheres were characterized for entrapment efficiency, mucoadhesive property by in vitro wash-off test and in-vitro drug release. The formulation F10 was selected as an ideal formulation based on the in vitro release profile which shows an extended drug release of 97.22 % upto12 hrs in phosphate buffer of pH 6.8. Surface morphology (SEM analysis) and drug-polymer interaction studies (FT-IR analysis) were performed only for the ideal formulation, F10. The microspheres were discrete, spherical in shape and had ideal surface morphology as confirmed by SEM and FT-IR studies indicated the lack of drug-polymer interactions in the ideal formulation, F10. The in vitro release data of all microsphere formulations were plotted in various kinetic equations to understand the mechanisms and kinetics of drug release. The ideal formulation, F10 followed Higuchi kinetics and value of "n," is calculated to be 0.36 indicated that the drug release shows Fickian diffusion.</i></p><p><strong>Keywords</strong>: <i>Carbopol 940P, HPMC (K 100 M), Ionotropic gelation method, Febuxostat, Sodium Alginate, Sodium CMC.</i></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_10019493 |
| institution | Zenodo |
| language | |
| publishDate | 2023 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | FORMULATION AND EVALUATION OF MUCOADHESIVE FEBUXOSTAT MICROSPHERES Bhukya Madhulatha , Zeenath Ruhy <p><i>The objective of the present study was to prepare and evaluate the mucoadhesive microspheres of Febuxostat. Febuxostat microspheres were prepared by ionotropic gelation method using polymers such as HPMC (K 100 M), Carbopol 940P, sodium CMC, sodium alginate, ethyl cellulose, methyl cellulose. Totally 12 different formulations of Febuxostat were prepared by using the above polymers. The microspheres were characterized for entrapment efficiency, mucoadhesive property by in vitro wash-off test and in-vitro drug release. The formulation F10 was selected as an ideal formulation based on the in vitro release profile which shows an extended drug release of 97.22 % upto12 hrs in phosphate buffer of pH 6.8. Surface morphology (SEM analysis) and drug-polymer interaction studies (FT-IR analysis) were performed only for the ideal formulation, F10. The microspheres were discrete, spherical in shape and had ideal surface morphology as confirmed by SEM and FT-IR studies indicated the lack of drug-polymer interactions in the ideal formulation, F10. The in vitro release data of all microsphere formulations were plotted in various kinetic equations to understand the mechanisms and kinetics of drug release. The ideal formulation, F10 followed Higuchi kinetics and value of "n," is calculated to be 0.36 indicated that the drug release shows Fickian diffusion.</i></p><p><strong>Keywords</strong>: <i>Carbopol 940P, HPMC (K 100 M), Ionotropic gelation method, Febuxostat, Sodium Alginate, Sodium CMC.</i></p> |
| title | FORMULATION AND EVALUATION OF MUCOADHESIVE FEBUXOSTAT MICROSPHERES |
| url | https://doi.org/10.5281/zenodo.10019493 |