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| Format: | Recurso digital |
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Zenodo
2023
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| Online Access: | https://doi.org/10.5281/zenodo.10077267 |
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Table of Contents:
- <p><i>Metronidazole (MTZ) is an anti- microbial/ anti-protozoal drug poorly soluble in aqueous medium. The solubility was enhanced by dispersion in poly ethylene glycol at a controlled temperature and recrystallized with n-hexane then resultant powder washed severally with distilled water to obtained a clear slightly colloidal/ nano sized powder. The recrystallized powder was analyzed for purity using the thermo-gravimetric method and possible structural loss and interaction applying the FTIR, particle size analysis using scanning electron microscopy(SEM) then compared for powder flow and compressibility index with untreated metronidazole powder. The crystallized and non-crystallized mtz powders were formulated into granules and tagged batch A and B respectively with same concentrations of excipients then eventually compressed into tablets. Various physico-technical properties of the granules were analyzed for both batches and there after compressed to tablets. The resulting tablets were determined for hardness, friability, dissolution and content of active ingredient while the flow rate of granules from the batches were 4.59±0.05959 and 3.24±0.0082, angle of repose (θ) at 32.9±0.3399 and 35.1±0.2625, Hausner's ratio 1.20±0.024 and 1.17±0.033, friability at 0.05 and 0.38, compressibility index 0.16±0.012 and 0.15±0.024, % drug release within 60 minutes at 110.75±12.510 and 127.5±20.241 while percentage(%) drug content was 80.2 and 105 respectively for the batches A and B.</i></p><p><i><strong>Key words</strong>: metronidazole powder, tablets, solid dispersions, solvent evaporation, formulation studies</i></p>