Ethyl carbamate in fruit spirits - Health risk assessment
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| Natura: | Recurso digital |
| Lingua: | inglese |
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Zenodo
2023
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| _version_ | 1866902216927870976 |
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| author | Kusonić, Dejan Bijelić, Katarina Kladar, Nebojša Torović, Ljilja Srđenović Čonić, Branislava |
| author_facet | Kusonić, Dejan Bijelić, Katarina Kladar, Nebojša Torović, Ljilja Srđenović Čonić, Branislava |
| contents | <p>The latest World Health Organization research revealed that 3 million deaths every year result from harmful use of alcohol, due to the presence of compounds, including ethyl carbamate (EC), that can have potentially carcinogenic effect. The aims of this study are determination of EC content in fruit spirits, comparison of the obtained values with the limit proposed by the International Alliance for Responsible Alcohol Consumption and comparative health risk assessment caused by the fruit spirits consumption. Fruit spirit samples (134, Republic of Serbia) were analyzed using GC-MS. Risk was assessed using the margin of exposure (MOE) and excess lifetime cancer risk approach, based on the oral slope factor (1) or virtually safe dose (2). The EC content was above limit of 0.4 mg/L in 95% of samples. Higher content in plum spirits was statistically significant. For men, 98% of the samples showed MOE values below the limit of 10 000 for average consumption, i.e., 100% for chronic heavy drinkers, while for women it ranged from 79% for average consumption to 99% for chronic heavy drinkers. Depending on the approach, already at average consumption: (1) no sample had a negligible cancer risk, regardless of gender; (2) more than 88% of the samples represented a risk to women’s health, i.e., 99% to men’s health. Research has shown a significant presence of EC in fruit spirits. It is necessary to implement measures during production to prevent the occurrence of EC, as well as legally regulate the maximum allowed concentration of EC in fruit spirits.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_10978651 |
| institution | Zenodo |
| language | eng |
| publishDate | 2023 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Ethyl carbamate in fruit spirits - Health risk assessment Kusonić, Dejan Bijelić, Katarina Kladar, Nebojša Torović, Ljilja Srđenović Čonić, Branislava ethyl carbamate MOE carcinogenic risk fruit spirits <p>The latest World Health Organization research revealed that 3 million deaths every year result from harmful use of alcohol, due to the presence of compounds, including ethyl carbamate (EC), that can have potentially carcinogenic effect. The aims of this study are determination of EC content in fruit spirits, comparison of the obtained values with the limit proposed by the International Alliance for Responsible Alcohol Consumption and comparative health risk assessment caused by the fruit spirits consumption. Fruit spirit samples (134, Republic of Serbia) were analyzed using GC-MS. Risk was assessed using the margin of exposure (MOE) and excess lifetime cancer risk approach, based on the oral slope factor (1) or virtually safe dose (2). The EC content was above limit of 0.4 mg/L in 95% of samples. Higher content in plum spirits was statistically significant. For men, 98% of the samples showed MOE values below the limit of 10 000 for average consumption, i.e., 100% for chronic heavy drinkers, while for women it ranged from 79% for average consumption to 99% for chronic heavy drinkers. Depending on the approach, already at average consumption: (1) no sample had a negligible cancer risk, regardless of gender; (2) more than 88% of the samples represented a risk to women’s health, i.e., 99% to men’s health. Research has shown a significant presence of EC in fruit spirits. It is necessary to implement measures during production to prevent the occurrence of EC, as well as legally regulate the maximum allowed concentration of EC in fruit spirits.</p> |
| title | Ethyl carbamate in fruit spirits - Health risk assessment |
| topic | ethyl carbamate MOE carcinogenic risk fruit spirits |
| url | https://doi.org/10.5281/zenodo.10978651 |