Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome
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2024
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| _version_ | 1866902072525324288 |
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| author | Viswanath, Shruthi Majila, Kartik |
| author_facet | Viswanath, Shruthi Majila, Kartik |
| contents | <p>Histone deacetylases (HDACs) 1 and 2 are Class I HDACs that are members of several transcriptional regulatory complexes including coREST, MIER, NuRD, and SIN3. The interaction of each HDAC within the complex is undefined. Our studies utilize Affinity Purification and Crosslinking Mass Spectrometry to define HDAC1 and 2 interactions. We determined the structures of NuRD, SIN3A, and coREST by integrative structural modeling.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_11498577 |
| institution | Zenodo |
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| publishDate | 2024 |
| publisher | Zenodo |
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| spellingShingle | Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome Viswanath, Shruthi Majila, Kartik HDAC1 HDAC2 Integrative Structural Modeling NuRD Sin3A coREST MIER XL-MS <p>Histone deacetylases (HDACs) 1 and 2 are Class I HDACs that are members of several transcriptional regulatory complexes including coREST, MIER, NuRD, and SIN3. The interaction of each HDAC within the complex is undefined. Our studies utilize Affinity Purification and Crosslinking Mass Spectrometry to define HDAC1 and 2 interactions. We determined the structures of NuRD, SIN3A, and coREST by integrative structural modeling.</p> |
| title | Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome |
| topic | HDAC1 HDAC2 Integrative Structural Modeling NuRD Sin3A coREST MIER XL-MS |
| url | https://doi.org/10.5281/zenodo.11498577 |