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2024
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| Online Access: | https://doi.org/10.5281/zenodo.11640398 |
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| author | G. Durgadevi* |
| author_facet | G. Durgadevi* |
| contents | <div> <p><em><span>Membrane-moderated transdermal systems of<span> </span><span> </span>Fluvastatin Sodium liposomes were prepared by incorporating the drug reservoir within a shallow compartment moulded from a drug-impermeable backing membrane and 2% w/v cellulose acetate rate-controlling membrane . The pharmacokinetic performance of <span> </span>Fluvastatin Sodium following transdermal administration was compared with that of oral administration. This study was carried out in a randomized cross-over design in male New Zealand albino rabbits. The estimation of <span> </span>Fluvastatin Sodiumin plasma was carried out by LC-MS/MS method. The parameters such as maximum plasma concentration (C max), time for peak plasma concentration (t max), mean residence time (MRT) and area under curve (AUC 0 - ∞) were significantly (P< 0.001) differed following transdermal administration compared to oral administration. The relative bioavailability of <span> </span>Fluvastatin Sodium was increased about nine fold after transdermal administration as compared to oral delivery. This may be due to the avoidance of first pass effect of <span> </span>Fluvastatin Sodium.<span> The concentration of </span><span> </span>Fluvastatin Sodium <span>in plasma was found to be stabilized and maintained in a narrow range over the study period up to 24 hrs for transdermal formulation where as the concentration was decreased rapidly up on oral administration.</span> It was concluded that the relative rate of extensive first pass metabolism was significantly reduced in transdermal administration, resulted in increased relative bioavailability and reduced frequency of administration.</span></em></p> <p><strong><em><span>Keywords</span></em></strong><em><span>:<span> </span>Fluvastatin Sodium,<span> </span>Liposomes, Transdermal systems, LC-MS/MS, In-vivo studies.</span></em></p> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_11640398 |
| institution | Zenodo |
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| publishDate | 2024 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | COMPARATIVE BIOAVAILABILITY EVALUATION OF FLUVASTATIN SODIUM AFTER ORAL AND TRANSDERMAL ADMINISTRATION IN RABBITS G. Durgadevi* <div> <p><em><span>Membrane-moderated transdermal systems of<span> </span><span> </span>Fluvastatin Sodium liposomes were prepared by incorporating the drug reservoir within a shallow compartment moulded from a drug-impermeable backing membrane and 2% w/v cellulose acetate rate-controlling membrane . The pharmacokinetic performance of <span> </span>Fluvastatin Sodium following transdermal administration was compared with that of oral administration. This study was carried out in a randomized cross-over design in male New Zealand albino rabbits. The estimation of <span> </span>Fluvastatin Sodiumin plasma was carried out by LC-MS/MS method. The parameters such as maximum plasma concentration (C max), time for peak plasma concentration (t max), mean residence time (MRT) and area under curve (AUC 0 - ∞) were significantly (P< 0.001) differed following transdermal administration compared to oral administration. The relative bioavailability of <span> </span>Fluvastatin Sodium was increased about nine fold after transdermal administration as compared to oral delivery. This may be due to the avoidance of first pass effect of <span> </span>Fluvastatin Sodium.<span> The concentration of </span><span> </span>Fluvastatin Sodium <span>in plasma was found to be stabilized and maintained in a narrow range over the study period up to 24 hrs for transdermal formulation where as the concentration was decreased rapidly up on oral administration.</span> It was concluded that the relative rate of extensive first pass metabolism was significantly reduced in transdermal administration, resulted in increased relative bioavailability and reduced frequency of administration.</span></em></p> <p><strong><em><span>Keywords</span></em></strong><em><span>:<span> </span>Fluvastatin Sodium,<span> </span>Liposomes, Transdermal systems, LC-MS/MS, In-vivo studies.</span></em></p> </div> |
| title | COMPARATIVE BIOAVAILABILITY EVALUATION OF FLUVASTATIN SODIUM AFTER ORAL AND TRANSDERMAL ADMINISTRATION IN RABBITS |
| url | https://doi.org/10.5281/zenodo.11640398 |