Rabies virus isolated from insectivorous bats induces different inflammatory responses in experimental model
Fuente:
Zenodo
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Recurso digital |
| Veröffentlicht: |
Zenodo
2022
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866901479879606272 |
|---|---|
| author | Motta, Gabriela Hering Guimarães, Leticia Patrícia Fernandes, Elaine Raniero Guedes, Fernanda De Sá, Lilian Rose Marques Dos Ramos Silva, Sandriana Ribeiro, Orlando Garcia Katz, Iana Suly Santos |
| author_facet | Motta, Gabriela Hering Guimarães, Leticia Patrícia Fernandes, Elaine Raniero Guedes, Fernanda De Sá, Lilian Rose Marques Dos Ramos Silva, Sandriana Ribeiro, Orlando Garcia Katz, Iana Suly Santos |
| contents | (Uploaded by Plazi for the Bat Literature Project) Rabies virus (RABV) is a neurotropic virus that causes fatal neuroinflammation in mammals. The insectivorous bat RABV strains are less pathogenic for mice than strains associated with other reservoirs. We characterized the tissue inflammatory response in the CNS of RABV isolated from insectivorous bats. Eptesicus furinalis (EPBRV)infected mice had a robust inflammatory response and a greater amount of IL-1β, IL-6 and TNF-α, while Myotis nigricans (MNBRV)-infected mice showed a higher expression of IL-17 and greater activation of IFN-β. New approaches to understand the inflammatory response to different mechanisms of action may provide insights for the development of novel therapies for rabies. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_13476637 |
| institution | Zenodo |
| language | |
| publishDate | 2022 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Rabies virus isolated from insectivorous bats induces different inflammatory responses in experimental model Motta, Gabriela Hering Guimarães, Leticia Patrícia Fernandes, Elaine Raniero Guedes, Fernanda De Sá, Lilian Rose Marques Dos Ramos Silva, Sandriana Ribeiro, Orlando Garcia Katz, Iana Suly Santos Biodiversity Mammalia Chiroptera Chordata Animalia bats bat (Uploaded by Plazi for the Bat Literature Project) Rabies virus (RABV) is a neurotropic virus that causes fatal neuroinflammation in mammals. The insectivorous bat RABV strains are less pathogenic for mice than strains associated with other reservoirs. We characterized the tissue inflammatory response in the CNS of RABV isolated from insectivorous bats. Eptesicus furinalis (EPBRV)infected mice had a robust inflammatory response and a greater amount of IL-1β, IL-6 and TNF-α, while Myotis nigricans (MNBRV)-infected mice showed a higher expression of IL-17 and greater activation of IFN-β. New approaches to understand the inflammatory response to different mechanisms of action may provide insights for the development of novel therapies for rabies. |
| title | Rabies virus isolated from insectivorous bats induces different inflammatory responses in experimental model |
| topic | Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
| url | https://doi.org/10.5281/zenodo.13476637 |