The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity
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2018
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| author | Pavlovich, Stephanie S. Lovett, Sean P. Koroleva, Galina Guito, Jonathan C. Arnold, Catherine E. Nagle, Elyse R. Kulcsar, Kirsten Lee, Albert Thibaud-Nissen, Françoise Hume, Adam J. Mühlberger, Elke Uebelhoer, Luke S. Towner, Jonathan S. Rabadan, Raul Sanchez-Lockhart, Mariano Kepler, Thomas B. Palacios, Gustavo |
| author_facet | Pavlovich, Stephanie S. Lovett, Sean P. Koroleva, Galina Guito, Jonathan C. Arnold, Catherine E. Nagle, Elyse R. Kulcsar, Kirsten Lee, Albert Thibaud-Nissen, Françoise Hume, Adam J. Mühlberger, Elke Uebelhoer, Luke S. Towner, Jonathan S. Rabadan, Raul Sanchez-Lockhart, Mariano Kepler, Thomas B. Palacios, Gustavo |
| contents | (Uploaded by Plazi for the Bat Literature Project) Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer cell receptors, MHC class I genes, and type I interferons, which dramatically differ from their functional counterparts in other mammals. Such concerted evolution of key components of bat immunity is strongly suggestive of novel modes of antiviral defense. An evaluation of the theoretical function of these genes suggests that an inhibitory immune state may exist in bats. Based on our findings, we hypothesize that tolerance of viral infection, rather than enhanced potency of antiviral defenses, may be a key mechanism by which bats asymptomatically host viruses that are pathogenic in humans. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_13524330 |
| institution | Zenodo |
| language | |
| publishDate | 2018 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity Pavlovich, Stephanie S. Lovett, Sean P. Koroleva, Galina Guito, Jonathan C. Arnold, Catherine E. Nagle, Elyse R. Kulcsar, Kirsten Lee, Albert Thibaud-Nissen, Françoise Hume, Adam J. Mühlberger, Elke Uebelhoer, Luke S. Towner, Jonathan S. Rabadan, Raul Sanchez-Lockhart, Mariano Kepler, Thomas B. Palacios, Gustavo antiviral immunity filovirus genome innate immunity natural killer cell receptors type I interferon Biodiversity Mammalia Chiroptera Chordata Animalia bats bat (Uploaded by Plazi for the Bat Literature Project) Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer cell receptors, MHC class I genes, and type I interferons, which dramatically differ from their functional counterparts in other mammals. Such concerted evolution of key components of bat immunity is strongly suggestive of novel modes of antiviral defense. An evaluation of the theoretical function of these genes suggests that an inhibitory immune state may exist in bats. Based on our findings, we hypothesize that tolerance of viral infection, rather than enhanced potency of antiviral defenses, may be a key mechanism by which bats asymptomatically host viruses that are pathogenic in humans. |
| title | The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity |
| topic | antiviral immunity filovirus genome innate immunity natural killer cell receptors type I interferon Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
| url | https://doi.org/10.5281/zenodo.13524330 |