Molecular characterisation of Toll-like receptors in the black flying fox Pteropus alecto
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| Format: | Recurso digital |
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Zenodo
2011
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| _version_ | 1866902085482577920 |
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| author | Cowled, Christopher Baker, Michelle Tachedjian, Mary Zhou, Peng Bulach, Dieter Wang, Lin Fa |
| author_facet | Cowled, Christopher Baker, Michelle Tachedjian, Mary Zhou, Peng Bulach, Dieter Wang, Lin Fa |
| contents | (Uploaded by Plazi for the Bat Literature Project) Bats are believed to be reservoir hosts for a number of emerging and re-emerging viruses, many of which are responsible for illness and mortality in humans, livestock and other animals. In other vertebrates, early responses to viral infection involve engagement of Toll-like receptors (TLRs), which induce changes in gene expression collectively leading to an "antiviral state" In this study we report the cloning and bioinformatic analysis of a complete set of TLRs from the black flying fox Pteropus alecto, and perform quantitative tissue expression analysis of the nucleic acid-sensing TLRs 3, 7, 8 and 9. Full-length mRNA transcripts from TLRs homologous to human TLRs 1-10 were sequenced, as well as a nearly intact TLR13 pseudogene that was spliced and polyadenylated. This prototype data can now be used to design functional studies of the bat innate immune system. © 2010. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_13527041 |
| institution | Zenodo |
| language | |
| publishDate | 2011 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Molecular characterisation of Toll-like receptors in the black flying fox Pteropus alecto Cowled, Christopher Baker, Michelle Tachedjian, Mary Zhou, Peng Bulach, Dieter Wang, Lin Fa Bat immunology Chiroptera Fruit bat Innate immunity Pteropus alecto Toll-like receptor Viral infection Biodiversity Mammalia Chiroptera Chordata Animalia bats bat (Uploaded by Plazi for the Bat Literature Project) Bats are believed to be reservoir hosts for a number of emerging and re-emerging viruses, many of which are responsible for illness and mortality in humans, livestock and other animals. In other vertebrates, early responses to viral infection involve engagement of Toll-like receptors (TLRs), which induce changes in gene expression collectively leading to an "antiviral state" In this study we report the cloning and bioinformatic analysis of a complete set of TLRs from the black flying fox Pteropus alecto, and perform quantitative tissue expression analysis of the nucleic acid-sensing TLRs 3, 7, 8 and 9. Full-length mRNA transcripts from TLRs homologous to human TLRs 1-10 were sequenced, as well as a nearly intact TLR13 pseudogene that was spliced and polyadenylated. This prototype data can now be used to design functional studies of the bat innate immune system. © 2010. |
| title | Molecular characterisation of Toll-like receptors in the black flying fox Pteropus alecto |
| topic | Bat immunology Chiroptera Fruit bat Innate immunity Pteropus alecto Toll-like receptor Viral infection Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
| url | https://doi.org/10.5281/zenodo.13527041 |