Serological evidence of influenza A viruses in frugivorous bats from Africa
Fuente:
Zenodo
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Recurso digital |
| Publié: |
Zenodo
2015
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1866901443194126336 |
|---|---|
| author | Freidl, Gudrun Stephanie Binger, Tabea Müller, Marcel Alexander de Bruin, Erwin van Beek, Janko Corman, Victor Max Rasche, Andrea Drexler, Jan Felix Sylverken, Augustina Oppong, Samuel K. Adu-Sarkodie, Yaw Tschapka, Marco Cottontail, Veronika M. Drosten, Christian Koopmans, Marion |
| author_facet | Freidl, Gudrun Stephanie Binger, Tabea Müller, Marcel Alexander de Bruin, Erwin van Beek, Janko Corman, Victor Max Rasche, Andrea Drexler, Jan Felix Sylverken, Augustina Oppong, Samuel K. Adu-Sarkodie, Yaw Tschapka, Marco Cottontail, Veronika M. Drosten, Christian Koopmans, Marion |
| contents | (Uploaded by Plazi for the Bat Literature Project) Bats are likely natural hosts for a range of zoonotic viruses such as Marburg, Ebola, Rabies, as well as for various Corona- and Paramyxoviruses. In 2009/10, researchers discovered RNA of two novel influenza virus subtypes – H17N10 and H18N11 – in Central and South American fruit bats. The identification of bats as possible additional reservoir for influenza A viruses raises questions about the role of this mammalian taxon in influenza A virus ecology and possible public health relevance. As molecular testing can be limited by a short time window in which the virus is present, serological testing provides information about past infections and virus spread in populations after the virus has been cleared. This study aimed at screening available sera from 100 free-ranging, frugivorous bats (Eidolon helvum) sampled in 2009/10 in Ghana, for the presence of antibodies against the complete panel of influenza A haemagglutinin (HA) types ranging from H1 to H18 by means of a protein microarray platform. This technique enables simultaneous serological testing against multiple recombinant HA-types in 5μl of serum. Preliminary results indicate serological evidence against avian influenza subtype H9 in about 30% of the animals screened, with low-level cross-reactivity to phylogenetically closely related subtypes H8 and H12. To our knowledge, this is the first report of serological evidence of influenza A viruses other than H17 and H18 in bats. As avian influenza subtype H9 is associated with human infections, the implications of our findings from a public health context remain to be investigated. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_13527746 |
| institution | Zenodo |
| language | |
| publishDate | 2015 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Serological evidence of influenza A viruses in frugivorous bats from Africa Freidl, Gudrun Stephanie Binger, Tabea Müller, Marcel Alexander de Bruin, Erwin van Beek, Janko Corman, Victor Max Rasche, Andrea Drexler, Jan Felix Sylverken, Augustina Oppong, Samuel K. Adu-Sarkodie, Yaw Tschapka, Marco Cottontail, Veronika M. Drosten, Christian Koopmans, Marion Biodiversity Mammalia Chiroptera Chordata Animalia bats bat (Uploaded by Plazi for the Bat Literature Project) Bats are likely natural hosts for a range of zoonotic viruses such as Marburg, Ebola, Rabies, as well as for various Corona- and Paramyxoviruses. In 2009/10, researchers discovered RNA of two novel influenza virus subtypes – H17N10 and H18N11 – in Central and South American fruit bats. The identification of bats as possible additional reservoir for influenza A viruses raises questions about the role of this mammalian taxon in influenza A virus ecology and possible public health relevance. As molecular testing can be limited by a short time window in which the virus is present, serological testing provides information about past infections and virus spread in populations after the virus has been cleared. This study aimed at screening available sera from 100 free-ranging, frugivorous bats (Eidolon helvum) sampled in 2009/10 in Ghana, for the presence of antibodies against the complete panel of influenza A haemagglutinin (HA) types ranging from H1 to H18 by means of a protein microarray platform. This technique enables simultaneous serological testing against multiple recombinant HA-types in 5μl of serum. Preliminary results indicate serological evidence against avian influenza subtype H9 in about 30% of the animals screened, with low-level cross-reactivity to phylogenetically closely related subtypes H8 and H12. To our knowledge, this is the first report of serological evidence of influenza A viruses other than H17 and H18 in bats. As avian influenza subtype H9 is associated with human infections, the implications of our findings from a public health context remain to be investigated. |
| title | Serological evidence of influenza A viruses in frugivorous bats from Africa |
| topic | Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
| url | https://doi.org/10.5281/zenodo.13527746 |