Modification by Ubiquitin-Like Proteins: Significance in Apoptosis and Autophagy Pathways
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| Format: | Recurso digital |
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2012
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| _version_ | 1866901271814864896 |
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| author | Cajee, Umar-Faruq Hull, Rodney Ntwasa, Monde |
| author_facet | Cajee, Umar-Faruq Hull, Rodney Ntwasa, Monde |
| contents | (Uploaded by Plazi for the Bat Literature Project) Ubiquitin-like proteins (Ubls) confer diverse functions on their target proteins. The modified proteins are involved in various biological processes, including DNA replication, signal transduction, cell cycle control, embryogenesis, cytoskeletal regulation, metabolism, stress response, homeostasis and mRNA processing. Modifiers such as SUMO, ATG12, ISG15, FAT10, URM1, and UFM have been shown to modify proteins thus conferring functions related to programmed cell death, autophagy and regulation of the immune system. Putative modifiers such as Domain With No Name (DWNN) have been identified in recent times but not fully characterized. In this review, we focus on cellular processes involving human Ubls and their targets. We review current progress in targeting these modifiers for drug design strategies. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_13530649 |
| institution | Zenodo |
| language | |
| publishDate | 2012 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Modification by Ubiquitin-Like Proteins: Significance in Apoptosis and Autophagy Pathways Cajee, Umar-Faruq Hull, Rodney Ntwasa, Monde DWNN SNAMA Ubls apoptosis autophagy cancer immune response p53 ubiquitin-like ubiquitin-proteasome Biodiversity Mammalia Chiroptera Chordata Animalia bats bat (Uploaded by Plazi for the Bat Literature Project) Ubiquitin-like proteins (Ubls) confer diverse functions on their target proteins. The modified proteins are involved in various biological processes, including DNA replication, signal transduction, cell cycle control, embryogenesis, cytoskeletal regulation, metabolism, stress response, homeostasis and mRNA processing. Modifiers such as SUMO, ATG12, ISG15, FAT10, URM1, and UFM have been shown to modify proteins thus conferring functions related to programmed cell death, autophagy and regulation of the immune system. Putative modifiers such as Domain With No Name (DWNN) have been identified in recent times but not fully characterized. In this review, we focus on cellular processes involving human Ubls and their targets. We review current progress in targeting these modifiers for drug design strategies. |
| title | Modification by Ubiquitin-Like Proteins: Significance in Apoptosis and Autophagy Pathways |
| topic | DWNN SNAMA Ubls apoptosis autophagy cancer immune response p53 ubiquitin-like ubiquitin-proteasome Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
| url | https://doi.org/10.5281/zenodo.13530649 |