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Zenodo
2025
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| Online Access: | https://doi.org/10.5281/zenodo.14561456 |
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Table of Contents:
- <p><strong><u><span>ABSTRACT</span></u></strong><strong><span>:</span></strong></p> <p><strong><span>Background: </span></strong><span>Blood transfusion is a natural lifesaving medicine which<span> </span>has a significant role in treating the patients. However this can also be<span> </span>associated with transfusion reactions as well. Presenting from mild<span> </span>reaction to fatal consequences. In this view the appropriate usage of<span> </span>blood and blood components and careful monitoring for early<span> </span>diagnosis and management of transfusion reactions are essential for<span> </span>patient<span> </span>safety<strong>. Materials and Methods</strong>: Retrospective observational analysis done<span> </span>from January 2023 – August 2024 in Blood centre, Apollo hospitals,<span> </span>health city, Visakhapatnam. The leukodepleted blood components<span> </span>utilized<span> </span>to<span> </span>minimize<span> </span>transfusion<span> </span>reactions.<strong> Results: </strong>Total number of buffy coat removal blood and blood<span> </span>components issued is 8083 out of which 11 (0.13%) cases reported<span> </span>transfusion reaction. Combination of washed RBC and followed by<span> </span>leukodepleted filter transfused in these 11 patients and in 57cases for<span> </span>the clinically indicated patients. These patients had successful<span> </span>transfusion. On further evaluation of these patients, adverse reaction<span> </span>rate was 0% .And proactively prevented adverse reaction in multiple<span> </span>transfusions of 910 cases by utilizing leucodepleted blood<span> </span>components<strong>. Conclusion:<span> </span>“PPPP”<span> </span>the<span> </span></strong>blood<span> </span>components<span> </span>therapy<span> </span>ensures<span> </span><strong>the<span> </span></strong>right<span> </span><strong>p</strong>roduct is administered to the - right <strong>p</strong>atient at the right time for the<span> </span>appropriate indication- which is crucial in preventing transfusion<span> </span>reactions<span> </span>and<span> </span>promoting<span> </span>patient<span> </span>safety.<strong> </strong>The use of Leucodepleted blood components helps in reducing the risk<span> </span>of blood transfusion reactions. When combined with washed packed<span> </span>red<span> </span>blood<span> </span>cells,<span> </span>it<span> </span>provides<span> </span>an<span> </span>additional<span> </span>layer<span> </span>of safety<span> </span>in<span> </span>preventing reactions in post transfusion reactions. The combination of washed<span> </span>RBC and leucodepleted filter has clinical benefit by preventing any<span> </span>obstacles for treating clinicians and surgeons allowing for improved<span> </span>patient<span> </span>care.</span></p> <p><strong><span> </span></strong></p> <p><strong><em><span>Keywords:<span> </span>Transfusion<span> </span>reactions,<span> </span>leukodepleted<span> </span>packed<span> </span>red<span> </span>cells,<span> </span>washed<span> </span>red<span> </span>blood<span> </span>cells.</span></em></strong></p> <p><strong><em><span> </span></em></strong></p>