Enregistré dans:
| Auteurs principaux: | , , , |
|---|---|
| Format: | Recurso digital |
| Langue: | |
| Publié: |
Zenodo
2025
|
| Accès en ligne: | https://doi.org/10.5281/zenodo.14586466 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1866902329053151232 |
|---|---|
| author | Hong, Sung Eun Suh, Kyung-Suk Kim, Won Choi, Murim |
| author_facet | Hong, Sung Eun Suh, Kyung-Suk Kim, Won Choi, Murim |
| contents | <p>This dataset contains data associated with the following article:</p> <blockquote> <p>Hong, S.E., Mun, S.J., Lee, Y.J. <em>et al.</em> <strong>Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis</strong>. <em>Nat Genet</em> (2025). https://doi.org/10.1038/s41588-025-02237-8</p> </blockquote> <p> </p> <p>This dataset includes following:</p> <ul> <li>Gene expression matrices per sample obtained from cellranger output</li> <li>Processed snRNA-seq data with cell-level and sample-level metadata in Seurat v4 format</li> <li>hdWGCNA results including harmonized module expression (hME) values for each single cell and module information</li> <li>Expression and covariate matrices used for sc-eQTL analysis</li> <li>Full summary statistics (including non-significant pairs) of sc-eQTLs (liver-eQTL, MASLD-eQTL, and control-eQTL)</li> <li>A table of significant liver-eQTLs and ieQTLs with comprehensive annotations</li> <li>A list of GWAS-colocalizing liver-eQTLs</li> <li>A list of 601 quartets composed of ieGenes, ieSNPs, interacting cell states, and transcription factors (TFs)</li> <li>Bulk RNA-seq data newly generated during revision <ul> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from hepatic organoids treated with EFHD1 siRNA</li> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from hepatic organoids treated with FOXO1-specific inhibitor AS1842856</li> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from HeG2 treated with FOXO1-specific inhibitor AS1842856</li> </ul> </li> </ul> <blockquote> <p> </p> </blockquote> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14586466 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Data for the article "Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis" Hong, Sung Eun Suh, Kyung-Suk Kim, Won Choi, Murim <p>This dataset contains data associated with the following article:</p> <blockquote> <p>Hong, S.E., Mun, S.J., Lee, Y.J. <em>et al.</em> <strong>Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis</strong>. <em>Nat Genet</em> (2025). https://doi.org/10.1038/s41588-025-02237-8</p> </blockquote> <p> </p> <p>This dataset includes following:</p> <ul> <li>Gene expression matrices per sample obtained from cellranger output</li> <li>Processed snRNA-seq data with cell-level and sample-level metadata in Seurat v4 format</li> <li>hdWGCNA results including harmonized module expression (hME) values for each single cell and module information</li> <li>Expression and covariate matrices used for sc-eQTL analysis</li> <li>Full summary statistics (including non-significant pairs) of sc-eQTLs (liver-eQTL, MASLD-eQTL, and control-eQTL)</li> <li>A table of significant liver-eQTLs and ieQTLs with comprehensive annotations</li> <li>A list of GWAS-colocalizing liver-eQTLs</li> <li>A list of 601 quartets composed of ieGenes, ieSNPs, interacting cell states, and transcription factors (TFs)</li> <li>Bulk RNA-seq data newly generated during revision <ul> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from hepatic organoids treated with EFHD1 siRNA</li> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from hepatic organoids treated with FOXO1-specific inhibitor AS1842856</li> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from HeG2 treated with FOXO1-specific inhibitor AS1842856</li> </ul> </li> </ul> <blockquote> <p> </p> </blockquote> |
| title | Data for the article "Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis" |
| url | https://doi.org/10.5281/zenodo.14586466 |