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| Main Authors: | , , , |
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| Format: | Recurso digital |
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Zenodo
2025
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| Online Access: | https://doi.org/10.5281/zenodo.14586466 |
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Table of Contents:
- <p>This dataset contains data associated with the following article:</p> <blockquote> <p>Hong, S.E., Mun, S.J., Lee, Y.J. <em>et al.</em> <strong>Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis</strong>. <em>Nat Genet</em> (2025). https://doi.org/10.1038/s41588-025-02237-8</p> </blockquote> <p> </p> <p>This dataset includes following:</p> <ul> <li>Gene expression matrices per sample obtained from cellranger output</li> <li>Processed snRNA-seq data with cell-level and sample-level metadata in Seurat v4 format</li> <li>hdWGCNA results including harmonized module expression (hME) values for each single cell and module information</li> <li>Expression and covariate matrices used for sc-eQTL analysis</li> <li>Full summary statistics (including non-significant pairs) of sc-eQTLs (liver-eQTL, MASLD-eQTL, and control-eQTL)</li> <li>A table of significant liver-eQTLs and ieQTLs with comprehensive annotations</li> <li>A list of GWAS-colocalizing liver-eQTLs</li> <li>A list of 601 quartets composed of ieGenes, ieSNPs, interacting cell states, and transcription factors (TFs)</li> <li>Bulk RNA-seq data newly generated during revision <ul> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from hepatic organoids treated with EFHD1 siRNA</li> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from hepatic organoids treated with FOXO1-specific inhibitor AS1842856</li> <li>Bulk RNA-seq counts matrix and differentially expressed gene list from HeG2 treated with FOXO1-specific inhibitor AS1842856</li> </ul> </li> </ul> <blockquote> <p> </p> </blockquote>