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| Format: | Recurso digital |
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Zenodo
2025
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| Online Access: | https://doi.org/10.5281/zenodo.14600031 |
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Table of Contents:
- <p>This R script generates a box plot visualizing the average DNA methylation levels across three groups: Healthy, Down Syndrome without Dementia (DSwoD), and Down Syndrome with Dementia (DSwD). The methylation levels are computed as the average across 734,451 CpG sites for each individual, providing a global methylation profile for each group. The plot was created using the <code>ggplot2</code> package, with the boxes representing the interquartile range (IQR), horizontal white points indicating median methylation levels, and whiskers extending to 1.5 times the IQR. Group colors are used to distinguish Healthy (red), DSwoD (green), and DSwD (blue), illustrating variations in global methylation patterns among the groups. This visualization offers insights into methylation trends relevant to Down Syndrome and its associated neurodegenerative conditions. The script saves the plot as <code>improved_methylation_box_plot.png</code>.</p>