A Study on Biochemical response and toxicity profile in very low, and intermediate risk prostate cancer individuals after stereotactic body radiotherapy
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| Format: | Recurso digital |
| Langue: | anglais |
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2024
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| _version_ | 1866901504223346688 |
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| author | A. Kiran Kumar Nadiminti Madhavi B Sirisha |
| author_facet | A. Kiran Kumar Nadiminti Madhavi B Sirisha |
| contents | <p><strong>Introduction: </strong>Prostate cancer (PC) is the second most common cancer globally, with significant incidence in India. Various treatment options exist, but Stereotactic Body Radiotherapy (SBRT) is emerging as a precise method for managing very low, low, and intermediate-risk PC. This study aims to assess the efficacy and toxicity profile of SBRT in these patients. <strong>Methods:</strong> This prospective observational study at Omega Hospital, Hyderabad, involved 30 patients with localized prostate cancer treated with Stereotactic Body Radiotherapy (SBRT). Inclusion criteria included men over 18 years with a WHO performance status of 0-2. The study assessed PSA levels and toxicity profiles during and after treatment, following ethical approvals. <strong>Results:</strong> In this study, 40% of participants were under 65, 20% were over 76, and the rest were aged 66–75. Mean baseline PSA dropped significantly from 11.86 ng/dl to 0.71 ng/dl over 12 months post-SBRT. Most experienced grade 1 acute gastrointestinal and genitourinary toxicity, with no toxicity above grade 1 by three months. <strong>Conclusion: </strong>This study underscores SBRT’s effectiveness and safety in localized prostate cancer, showing significant PSA reduction and durable biochemical control. With mostly grade 1 acute gastrointestinal and genitourinary toxicity, SBRT proves to be a viable treatment option, offering effective cancer control and minimal impact on quality of life.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14621960 |
| institution | Zenodo |
| language | eng |
| publishDate | 2024 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | A Study on Biochemical response and toxicity profile in very low, and intermediate risk prostate cancer individuals after stereotactic body radiotherapy A. Kiran Kumar Nadiminti Madhavi B Sirisha Prostate Cancer, SBRT (Stereotactic Body Radiotherapy), Biochemical Control, Toxicity Profile, Quality of Life <p><strong>Introduction: </strong>Prostate cancer (PC) is the second most common cancer globally, with significant incidence in India. Various treatment options exist, but Stereotactic Body Radiotherapy (SBRT) is emerging as a precise method for managing very low, low, and intermediate-risk PC. This study aims to assess the efficacy and toxicity profile of SBRT in these patients. <strong>Methods:</strong> This prospective observational study at Omega Hospital, Hyderabad, involved 30 patients with localized prostate cancer treated with Stereotactic Body Radiotherapy (SBRT). Inclusion criteria included men over 18 years with a WHO performance status of 0-2. The study assessed PSA levels and toxicity profiles during and after treatment, following ethical approvals. <strong>Results:</strong> In this study, 40% of participants were under 65, 20% were over 76, and the rest were aged 66–75. Mean baseline PSA dropped significantly from 11.86 ng/dl to 0.71 ng/dl over 12 months post-SBRT. Most experienced grade 1 acute gastrointestinal and genitourinary toxicity, with no toxicity above grade 1 by three months. <strong>Conclusion: </strong>This study underscores SBRT’s effectiveness and safety in localized prostate cancer, showing significant PSA reduction and durable biochemical control. With mostly grade 1 acute gastrointestinal and genitourinary toxicity, SBRT proves to be a viable treatment option, offering effective cancer control and minimal impact on quality of life.</p> |
| title | A Study on Biochemical response and toxicity profile in very low, and intermediate risk prostate cancer individuals after stereotactic body radiotherapy |
| topic | Prostate Cancer, SBRT (Stereotactic Body Radiotherapy), Biochemical Control, Toxicity Profile, Quality of Life |
| url | https://doi.org/10.5281/zenodo.14621960 |