Current Trends and Challenges in Sustained-Release Tablet Formulations: A Comprehensive Review
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2025
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| _version_ | 1866901198608531456 |
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| author | Mangesh Dagale*, Dr. Nilesh Gorde, Kartik Shinde, Ashwini Karnakoti, Prajwal Birajdar |
| author_facet | Mangesh Dagale*, Dr. Nilesh Gorde, Kartik Shinde, Ashwini Karnakoti, Prajwal Birajdar |
| contents | <p><span>The development of sustained release (SR) matrix tablets has garnered significant attention in modern pharmaceutical research owing to their ability to maintain prolonged therapeutic action, improve patient compliance, and enhance drug bioavailability. Among various approaches for achieving sustained release, the use of natural gums as matrix-forming agents has emerged as a promising strategy due to their biocompatibility, biodegradability, non-toxicity, and economic viability. This review focuses on the formulation, evaluation, and applications of SR matrix tablets, with a special emphasis on natural gums such as xanthan gum, guar gum, alginate, and karaya gum. The mechanisms of drug release from these hydrophilic matrices, including swelling, erosion, and diffusion, are discussed in detail. Key formulation parameters such as polymer concentration, drug solubility, and tablet hardness, which influence drug release kinetics, are analyzed. Furthermore, regulatory considerations, challenges in large-scale production, and potential future directions, such as the incorporation of nanomaterials or hybrid systems, are explored. By highlighting the critical role of natural gums in SR drug delivery, this review provides a comprehensive resource for researchers engaged in the development of advanced oral drug delivery systems.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14678430 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Current Trends and Challenges in Sustained-Release Tablet Formulations: A Comprehensive Review Mangesh Dagale*, Dr. Nilesh Gorde, Kartik Shinde, Ashwini Karnakoti, Prajwal Birajdar Sustained Release, Tablets, Delivery, Systems. <p><span>The development of sustained release (SR) matrix tablets has garnered significant attention in modern pharmaceutical research owing to their ability to maintain prolonged therapeutic action, improve patient compliance, and enhance drug bioavailability. Among various approaches for achieving sustained release, the use of natural gums as matrix-forming agents has emerged as a promising strategy due to their biocompatibility, biodegradability, non-toxicity, and economic viability. This review focuses on the formulation, evaluation, and applications of SR matrix tablets, with a special emphasis on natural gums such as xanthan gum, guar gum, alginate, and karaya gum. The mechanisms of drug release from these hydrophilic matrices, including swelling, erosion, and diffusion, are discussed in detail. Key formulation parameters such as polymer concentration, drug solubility, and tablet hardness, which influence drug release kinetics, are analyzed. Furthermore, regulatory considerations, challenges in large-scale production, and potential future directions, such as the incorporation of nanomaterials or hybrid systems, are explored. By highlighting the critical role of natural gums in SR drug delivery, this review provides a comprehensive resource for researchers engaged in the development of advanced oral drug delivery systems.</span></p> |
| title | Current Trends and Challenges in Sustained-Release Tablet Formulations: A Comprehensive Review |
| topic | Sustained Release, Tablets, Delivery, Systems. |
| url | https://doi.org/10.5281/zenodo.14678430 |