Prophylactic platelet transfusion threshold during therapy for adult acute myeloid leukemia: 10,000/microL versus 20,000/microL
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| Format: | Recurso digital |
| Langue: | anglais |
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Zenodo
1998
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| _version_ | 1866901174633889792 |
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| author | Tomas-Navarro, Jose Hernandez-Rivas, Jose Angel Ribera, Josep Maria Sancho, Juan Manuel Oriol, Albert Pujol, Misericordia Milla, Fuensanta Feliu, Evarist |
| author_facet | Tomas-Navarro, Jose Hernandez-Rivas, Jose Angel Ribera, Josep Maria Sancho, Juan Manuel Oriol, Albert Pujol, Misericordia Milla, Fuensanta Feliu, Evarist |
| contents | <p><strong>Background and objective: </strong>The threshold for prophylactic platelet transfusions has been classically established at 20,000/microL. In 48 patients with de novo acute myeloblastic leukemia (AML) we analyzed the effect of reducing the threshold for prophylactic platelet transfusion from 20,000/microL (group A) to 10,000/microL (group B) after induction and consolidation chemotherapy.</p> <p><strong>Design and methods: </strong>Forty-eight adult patients with de novo AML diagnosed in a single institution in a nine year period were enrolled in the study. Between January 1989 and December 1993 the patients received prophylactic platelet transfusions when their platelet count was below 20,000/microL (group A), and from January 1994 to March 1998 prophylactic platelet transfusions were indicated below 10,000/microL or between 10,000/microL and 20,000/microL if there was any consumption factor.</p> <p><strong>Results: </strong>The mean number (SD) of platelet transfusions during induction was 8.4 (5.3) in group A and 8.5 (5.5) in group B; and during consolidation 4.7 (3.4) in group A and 4.6 (3.8) in group B (p = n.s.). Excluding the cases with consumption factors from the analysis, group B patients required 34% fewer transfusions during induction and 15.5% fewer during consolidation (p = 0.04). There were no differences between groups regarding major bleeding episodes.</p> <p><strong>Interpretation and conclusions: </strong>Our data show that the threshold for prophylactic platelet transfusion can be safely set at 10,000 microL during induction and consolidation chemotherapy for adult patients with de novo AML.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14743016 |
| institution | Zenodo |
| language | eng |
| publishDate | 1998 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Prophylactic platelet transfusion threshold during therapy for adult acute myeloid leukemia: 10,000/microL versus 20,000/microL Tomas-Navarro, Jose Hernandez-Rivas, Jose Angel Ribera, Josep Maria Sancho, Juan Manuel Oriol, Albert Pujol, Misericordia Milla, Fuensanta Feliu, Evarist Hemorrhage/prevention & control Leukemia, Myeloid/complications Platelet Count Platelet Transfusion/statistics & numerical data Thrombocytopenia/therapy <p><strong>Background and objective: </strong>The threshold for prophylactic platelet transfusions has been classically established at 20,000/microL. In 48 patients with de novo acute myeloblastic leukemia (AML) we analyzed the effect of reducing the threshold for prophylactic platelet transfusion from 20,000/microL (group A) to 10,000/microL (group B) after induction and consolidation chemotherapy.</p> <p><strong>Design and methods: </strong>Forty-eight adult patients with de novo AML diagnosed in a single institution in a nine year period were enrolled in the study. Between January 1989 and December 1993 the patients received prophylactic platelet transfusions when their platelet count was below 20,000/microL (group A), and from January 1994 to March 1998 prophylactic platelet transfusions were indicated below 10,000/microL or between 10,000/microL and 20,000/microL if there was any consumption factor.</p> <p><strong>Results: </strong>The mean number (SD) of platelet transfusions during induction was 8.4 (5.3) in group A and 8.5 (5.5) in group B; and during consolidation 4.7 (3.4) in group A and 4.6 (3.8) in group B (p = n.s.). Excluding the cases with consumption factors from the analysis, group B patients required 34% fewer transfusions during induction and 15.5% fewer during consolidation (p = 0.04). There were no differences between groups regarding major bleeding episodes.</p> <p><strong>Interpretation and conclusions: </strong>Our data show that the threshold for prophylactic platelet transfusion can be safely set at 10,000 microL during induction and consolidation chemotherapy for adult patients with de novo AML.</p> |
| title | Prophylactic platelet transfusion threshold during therapy for adult acute myeloid leukemia: 10,000/microL versus 20,000/microL |
| topic | Hemorrhage/prevention & control Leukemia, Myeloid/complications Platelet Count Platelet Transfusion/statistics & numerical data Thrombocytopenia/therapy |
| url | https://doi.org/10.5281/zenodo.14743016 |