| _version_ | 1866901622131523584 |
|---|---|
| author | Ximendes, Erving Rocha Silva, Uéslen Sales, Tasso de Oliveira Fernández, Nuria Sanz-Rodriguez, Francisco martin, Inocencio R. Jaque Garcia, Daniel |
| author_facet | Ximendes, Erving Rocha Silva, Uéslen Sales, Tasso de Oliveira Fernández, Nuria Sanz-Rodriguez, Francisco martin, Inocencio R. Jaque Garcia, Daniel |
| contents | <p><span>Some of the old and unrealizable dreams of biomedicine have become possible thanks to the appearance into scene of novel advanced materials such as luminescent nanothermometers, nanoparticles capable of provide a contactless thermal reading through their light emission properties. Luminescent nanothermometers have been already demonstrated to be capable of in vivo subcutaneous punctual thermal reading but their real application as diagnosis tools still requires demonstrating their actual capacity for the acquisition of <em>in vivo</em>, time-resolved subcutaneous thermal images. The transfer from 1D to 2D subcutaneous thermal sensing has been blocked during last years mainly due to the lack of high sensitivity luminescent nanothermometers operating in the infrared biological windows. In this work we demonstrate how core/shell engineering, in combination with selective rare earth doping, could be used to develop supersensitive infrared luminescent nanothermometers. Erbium, Thulium and Ytterbium core-shell LaF<sub>3</sub> nanoparticles, operating within the biological windows, provide thermal sensitivities as large as 5 %·</span><span><span>°</span></span><span>C<sup>-1</sup>. This “record” sensitivity has allowed for the final acquisition of subcutaneous thermal videos of a living animal. Subsequent analysis of thermal videos allowed for an unequivocal determination of intrinsic properties of subcutaneous tissues, opening the venue to the development of novel thermal imaging-based diagnosis tools.<span> </span></span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14775665 |
| institution | Zenodo |
| language | |
| publishDate | 2017 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | In Vivo Subcutaneous Thermal Video Recording by Supersensitive Infrared Nanothermometers Ximendes, Erving Rocha Silva, Uéslen Sales, Tasso de Oliveira Fernández, Nuria Sanz-Rodriguez, Francisco martin, Inocencio R. Jaque Garcia, Daniel <p><span>Some of the old and unrealizable dreams of biomedicine have become possible thanks to the appearance into scene of novel advanced materials such as luminescent nanothermometers, nanoparticles capable of provide a contactless thermal reading through their light emission properties. Luminescent nanothermometers have been already demonstrated to be capable of in vivo subcutaneous punctual thermal reading but their real application as diagnosis tools still requires demonstrating their actual capacity for the acquisition of <em>in vivo</em>, time-resolved subcutaneous thermal images. The transfer from 1D to 2D subcutaneous thermal sensing has been blocked during last years mainly due to the lack of high sensitivity luminescent nanothermometers operating in the infrared biological windows. In this work we demonstrate how core/shell engineering, in combination with selective rare earth doping, could be used to develop supersensitive infrared luminescent nanothermometers. Erbium, Thulium and Ytterbium core-shell LaF<sub>3</sub> nanoparticles, operating within the biological windows, provide thermal sensitivities as large as 5 %·</span><span><span>°</span></span><span>C<sup>-1</sup>. This “record” sensitivity has allowed for the final acquisition of subcutaneous thermal videos of a living animal. Subsequent analysis of thermal videos allowed for an unequivocal determination of intrinsic properties of subcutaneous tissues, opening the venue to the development of novel thermal imaging-based diagnosis tools.<span> </span></span></p> |
| title | In Vivo Subcutaneous Thermal Video Recording by Supersensitive Infrared Nanothermometers |
| url | https://doi.org/10.5281/zenodo.14775665 |