Supplementary material: Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based fMRI data of the ENIGMA-OCD consortium
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2025
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| author | Dzinalija, Nadza |
| author_facet | Dzinalija, Nadza |
| contents | <p>This content accompanies the supplement to the manuscript<em> Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based fMRI data of the ENIGMA-OCD consortium</em> (Dzinalija et al., 2025)<em>. </em>The processing manual and the quality control manual can be found here. </p> <p>The ridge plots attached here are full results of Figures 1B, 2B, and 3B of the manuscript and Figures S1B, S2B, and S3B of the supplement depicting whole-brain Bayesian multilevel models run using the Regional Bayesian Analysis toolbox (RBA; Chen et al., 2019). Whole-brain analyses were parcelated into the Schaefer-Yeo 7-network 200-parcel cortical atlas (Schaefer et al., 2018) and the Melbourne 32-region subcortical atlas (Tian et al., 2020). Results are presented according to contrast of interests: Executive function (EXEC; relative to baseline) and task load (LOAD; parametric modulation of increasing cognitive effort), and effects of interest: [Diagnosis = OCD or HC], [MED = medication], [AO = age of onset], [YBOCS = OCD severity], and [Intercept = task effect]. In addition, the task effect and case-control effect for the two contrasts of interest were investigated additionally by restricting analyses to only the Tower of London (TOL) tasks.</p> <p>P+ values denote the probability that there is increased brain activation in a given region of the Schaefer 200-parcel 7-network cortical atlas and Melbourne 32-region subcortical atlas. We used the guidelines proposed by Chen et al. (2019) to infer credibility of evidence, namely taking a positive posterior probability (P+) of <0.10 or >0.90 as indication of moderate evidence and, <0.05 or >0.95 or <0.025 or >0.975 as strong or very strong evidence, respectively. To interpret the pairwise comparisons presented as Group1-vs-Group2, posterior distributions to the right of the green no-effect line represent regions in which individuals in Group 1 show credible evidence for higher activation than individuals in Group 2. Regions with posterior distributions to the left of this line show credible evidence for higher activity in Group 2 than in Group 1. (Darker) red color represents regions in which individuals in Group 1 show moderate-to-very-strong evidence for higher activation than Group 2. (Darker) blue color represents regions in which Group 2 show moderate-to-very-strong evidence for higher activation than Group 1. Grey color represents regions in which there is no strong evidence of a difference between Group 1 and Group 2. Schaefer-Yeo 200-parcel atlas name abbreviations can be retrieved <a href="https://github.com/ThomasYeoLab/CBIG/tree/master/stable_projects/brain_parcellation/Schaefer2018_LocalGlobal/Parcellations">via this link.</a></p> |
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| spellingShingle | Supplementary material: Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based fMRI data of the ENIGMA-OCD consortium Dzinalija, Nadza <p>This content accompanies the supplement to the manuscript<em> Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based fMRI data of the ENIGMA-OCD consortium</em> (Dzinalija et al., 2025)<em>. </em>The processing manual and the quality control manual can be found here. </p> <p>The ridge plots attached here are full results of Figures 1B, 2B, and 3B of the manuscript and Figures S1B, S2B, and S3B of the supplement depicting whole-brain Bayesian multilevel models run using the Regional Bayesian Analysis toolbox (RBA; Chen et al., 2019). Whole-brain analyses were parcelated into the Schaefer-Yeo 7-network 200-parcel cortical atlas (Schaefer et al., 2018) and the Melbourne 32-region subcortical atlas (Tian et al., 2020). Results are presented according to contrast of interests: Executive function (EXEC; relative to baseline) and task load (LOAD; parametric modulation of increasing cognitive effort), and effects of interest: [Diagnosis = OCD or HC], [MED = medication], [AO = age of onset], [YBOCS = OCD severity], and [Intercept = task effect]. In addition, the task effect and case-control effect for the two contrasts of interest were investigated additionally by restricting analyses to only the Tower of London (TOL) tasks.</p> <p>P+ values denote the probability that there is increased brain activation in a given region of the Schaefer 200-parcel 7-network cortical atlas and Melbourne 32-region subcortical atlas. We used the guidelines proposed by Chen et al. (2019) to infer credibility of evidence, namely taking a positive posterior probability (P+) of <0.10 or >0.90 as indication of moderate evidence and, <0.05 or >0.95 or <0.025 or >0.975 as strong or very strong evidence, respectively. To interpret the pairwise comparisons presented as Group1-vs-Group2, posterior distributions to the right of the green no-effect line represent regions in which individuals in Group 1 show credible evidence for higher activation than individuals in Group 2. Regions with posterior distributions to the left of this line show credible evidence for higher activity in Group 2 than in Group 1. (Darker) red color represents regions in which individuals in Group 1 show moderate-to-very-strong evidence for higher activation than Group 2. (Darker) blue color represents regions in which Group 2 show moderate-to-very-strong evidence for higher activation than Group 1. Grey color represents regions in which there is no strong evidence of a difference between Group 1 and Group 2. Schaefer-Yeo 200-parcel atlas name abbreviations can be retrieved <a href="https://github.com/ThomasYeoLab/CBIG/tree/master/stable_projects/brain_parcellation/Schaefer2018_LocalGlobal/Parcellations">via this link.</a></p> |
| title | Supplementary material: Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based fMRI data of the ENIGMA-OCD consortium |
| url | https://doi.org/10.5281/zenodo.14800135 |