Comparative Invitro and Exvivo Evaluation of Transferosomal Patches for Enhanced Drug Delivery of Lisinopril Dihydrate
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2025
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| _version_ | 1866902032639590400 |
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| author | Aparanjitha R.*, Sunitha Reddy M. |
| author_facet | Aparanjitha R.*, Sunitha Reddy M. |
| contents | <p><span>The study was aimed to formulate transferosomal transdermal patches and to compare the drug release with normal transdermal patch of lisnopril dehydrate. Various kinds of surfactants such as Tween 80, Labrosol, Span 80 as edge activators and soya lecithin were used the formulation. The transferosomal formulations were prepared by sonication method. The formulations were evaluated for morphology, size, Zeta potential, entrapment efficiency. The preparation having labrosol as were found to have optimum deformability and highest entrapment when compared with other formulations. The optimized transferosomal formulation was further made into transdermal patches with help of gums HPMC 15cps , HPMC 5cps and plasticizers propylene glycol and polyethylene glycol 400 by solvent evaporation method. The normal transdermal patches were prepared by directly adding drug in the gum solution.<span> </span>Both the patches were evaluated for cumulative drug release in vitro and exvivo for 24hrs. The cumulative drug release of transferosomal patches after 24hrs was 96% in vitro. The amount of lisnopril in normal transdermal patches was 62% in vitro. The transferosomal patches have shown better permeation studies, the flux was found to be 28± 2.68 (µg/cm2/hr) and cumulative amount of the drug permeated was found to be (Q24) 960 ±0.94 µg/cm2. . The formulation prepared with nanaocarriers incomparision with normal patches have shown better results. From this study it can be concluded that nanaocarrier mediated transdermal drug delivery is the best way to enhance transdermal permeation of drugs through the skin</span><span>.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14848716 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Comparative Invitro and Exvivo Evaluation of Transferosomal Patches for Enhanced Drug Delivery of Lisinopril Dihydrate Aparanjitha R.*, Sunitha Reddy M. Transferosomes, Transdermal, Nanocarriers, Edge Activators. <p><span>The study was aimed to formulate transferosomal transdermal patches and to compare the drug release with normal transdermal patch of lisnopril dehydrate. Various kinds of surfactants such as Tween 80, Labrosol, Span 80 as edge activators and soya lecithin were used the formulation. The transferosomal formulations were prepared by sonication method. The formulations were evaluated for morphology, size, Zeta potential, entrapment efficiency. The preparation having labrosol as were found to have optimum deformability and highest entrapment when compared with other formulations. The optimized transferosomal formulation was further made into transdermal patches with help of gums HPMC 15cps , HPMC 5cps and plasticizers propylene glycol and polyethylene glycol 400 by solvent evaporation method. The normal transdermal patches were prepared by directly adding drug in the gum solution.<span> </span>Both the patches were evaluated for cumulative drug release in vitro and exvivo for 24hrs. The cumulative drug release of transferosomal patches after 24hrs was 96% in vitro. The amount of lisnopril in normal transdermal patches was 62% in vitro. The transferosomal patches have shown better permeation studies, the flux was found to be 28± 2.68 (µg/cm2/hr) and cumulative amount of the drug permeated was found to be (Q24) 960 ±0.94 µg/cm2. . The formulation prepared with nanaocarriers incomparision with normal patches have shown better results. From this study it can be concluded that nanaocarrier mediated transdermal drug delivery is the best way to enhance transdermal permeation of drugs through the skin</span><span>.</span></p> |
| title | Comparative Invitro and Exvivo Evaluation of Transferosomal Patches for Enhanced Drug Delivery of Lisinopril Dihydrate |
| topic | Transferosomes, Transdermal, Nanocarriers, Edge Activators. |
| url | https://doi.org/10.5281/zenodo.14848716 |