Preparation and Evaluation of a High-Efficacious Haemostatic Film with Chitosan and Alum and its Pharmacological Studies for Reducing Blood Loss
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2025
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| author | Malay Besra*, Mir Irfan Soyel, Biplab Kumar Chakra, Nilanjan Adhikari, Sumit Maji |
| author_facet | Malay Besra*, Mir Irfan Soyel, Biplab Kumar Chakra, Nilanjan Adhikari, Sumit Maji |
| contents | <p><span>The recent study was to investigate the synergistic activity of Chitosan, Alum, and PVA cross-linked haemostatic film to stop bleeding during the war and other accidental causes. In India around 30- 40% of uncontrolled haemorrhage responsible for trauma-related death. Formulation of haemostatic patches was done by solvent casting method Aim: To evaluate the synergistic effect of high efficacy Chitosan and Alum for controlling blood loss. Methodsc: Prepare chitosan and alum hemostatic flim and evaluate the film by Swelling ratio and Percentage moisture content. In-vitro evaluation of the haemostatic film were done by Platelet count and Whole blood clotting test. In-vivo evaluation of the haemostatic film were done by Rat liver laceration model, Rat jugular vein model and Rat femoral artery model under these models we evaluate Haemostatic time measurement. After that we have go for histological evaluation of lasiration liver tissue. Results: The haemostatic film prepare properly and the all the evaluation were done properly according to mention protocol. We observed good result of chitosan alam haemostatic film compare to alam and chitosan film. Conclusion: A complex was produced by cross-linking with Chitosan, alum, and polyvinyl alcohol to form a haemostatic film through the solvent casting method. By using in vitro blood clotting models and in vivo animal bleeding models, it can be determined that the synergistic qualities of the haemostatic agents alum and chitosan produce a greater haemostatic effect. As a result, the haemostatic film can be applied to blood loss management. The mechanism of action of homeostasis will be improved by more assessment of the several molecular pathways linked to blood coagulation</span><span>.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14851453 |
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| publishDate | 2025 |
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| spellingShingle | Preparation and Evaluation of a High-Efficacious Haemostatic Film with Chitosan and Alum and its Pharmacological Studies for Reducing Blood Loss Malay Besra*, Mir Irfan Soyel, Biplab Kumar Chakra, Nilanjan Adhikari, Sumit Maji Chitosan and Alum haemostatic film, Liver laceration model, Jugular vein model, Femoral artery model, Histopathology of liver. <p><span>The recent study was to investigate the synergistic activity of Chitosan, Alum, and PVA cross-linked haemostatic film to stop bleeding during the war and other accidental causes. In India around 30- 40% of uncontrolled haemorrhage responsible for trauma-related death. Formulation of haemostatic patches was done by solvent casting method Aim: To evaluate the synergistic effect of high efficacy Chitosan and Alum for controlling blood loss. Methodsc: Prepare chitosan and alum hemostatic flim and evaluate the film by Swelling ratio and Percentage moisture content. In-vitro evaluation of the haemostatic film were done by Platelet count and Whole blood clotting test. In-vivo evaluation of the haemostatic film were done by Rat liver laceration model, Rat jugular vein model and Rat femoral artery model under these models we evaluate Haemostatic time measurement. After that we have go for histological evaluation of lasiration liver tissue. Results: The haemostatic film prepare properly and the all the evaluation were done properly according to mention protocol. We observed good result of chitosan alam haemostatic film compare to alam and chitosan film. Conclusion: A complex was produced by cross-linking with Chitosan, alum, and polyvinyl alcohol to form a haemostatic film through the solvent casting method. By using in vitro blood clotting models and in vivo animal bleeding models, it can be determined that the synergistic qualities of the haemostatic agents alum and chitosan produce a greater haemostatic effect. As a result, the haemostatic film can be applied to blood loss management. The mechanism of action of homeostasis will be improved by more assessment of the several molecular pathways linked to blood coagulation</span><span>.</span></p> |
| title | Preparation and Evaluation of a High-Efficacious Haemostatic Film with Chitosan and Alum and its Pharmacological Studies for Reducing Blood Loss |
| topic | Chitosan and Alum haemostatic film, Liver laceration model, Jugular vein model, Femoral artery model, Histopathology of liver. |
| url | https://doi.org/10.5281/zenodo.14851453 |