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2025
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| Online Access: | https://doi.org/10.5281/zenodo.14874332 |
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| author | Devika.S ,Serman.S ,Kavitha.P ,Manojkumar ,Sujithkumar.M ,Yamuna.S ,Vasanth.R , Tamizharasan.K ,Pavidharani.C |
| author_facet | Devika.S ,Serman.S ,Kavitha.P ,Manojkumar ,Sujithkumar.M ,Yamuna.S ,Vasanth.R , Tamizharasan.K ,Pavidharani.C |
| contents | <p>Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social <br>interaction, communication difficulties, and repetitive behaviours. Emerging evidence suggests that serotonin (5-<br>hydroxytryptamine, 5-HT) plays a pivotal role in ASD pathophysiology. Serotonin's widespread influence on <br>neurodevelopmental processes, including neurogenesis, synaptogenesis, and neural circuit formation, underscores its <br>significance in ASD research. Hyperserotonemia, a condition marked by elevated blood serotonin levels, has been <br>identified as the first biomarker of ASD, affecting approximately 30% of individuals with the disorder. Genetic studies <br>implicate serotonin transporter (SERT) gene variations, such as the Ala56 variant, in ASD-associated behavioural<br>abnormalities. Functional imaging and biochemical studies reveal disruptions in serotonin synthesis, receptor binding, <br>and transporter activity in autistic individuals.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14874332 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Serotonin dysfunction in autism spectrum disorder: A neurological perspective Devika.S ,Serman.S ,Kavitha.P ,Manojkumar ,Sujithkumar.M ,Yamuna.S ,Vasanth.R , Tamizharasan.K ,Pavidharani.C <p>Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social <br>interaction, communication difficulties, and repetitive behaviours. Emerging evidence suggests that serotonin (5-<br>hydroxytryptamine, 5-HT) plays a pivotal role in ASD pathophysiology. Serotonin's widespread influence on <br>neurodevelopmental processes, including neurogenesis, synaptogenesis, and neural circuit formation, underscores its <br>significance in ASD research. Hyperserotonemia, a condition marked by elevated blood serotonin levels, has been <br>identified as the first biomarker of ASD, affecting approximately 30% of individuals with the disorder. Genetic studies <br>implicate serotonin transporter (SERT) gene variations, such as the Ala56 variant, in ASD-associated behavioural<br>abnormalities. Functional imaging and biochemical studies reveal disruptions in serotonin synthesis, receptor binding, <br>and transporter activity in autistic individuals.</p> |
| title | Serotonin dysfunction in autism spectrum disorder: A neurological perspective |
| url | https://doi.org/10.5281/zenodo.14874332 |