NLRC4 regulates a unique immunologic program.
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2025
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| _version_ | 1866902135446175744 |
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| author | Mamoor, Shahan |
| author_facet | Mamoor, Shahan |
| contents | <p>We have defined transcription control of the innate immune system by the NLR family member NOD2 and its pathologic counterpart in the inflammatory bowel disease Crohn's Disease, described NLRC4 as an inhibitor of the interferon signaling pathway, and demonstrated that the NLR family member NLRP10 regulates interactions between the adaptive and innate arms of the immune system (particularly at the B-cell immunologic synapse involving CD40 and the BAFF receptor) as well as discovering novel surveillance activities for an NLR protein, wherein NLRP10 functioned as a sensor of cell cycle speed. </p> <p>Here we utilized whole transcriptome technologies, human cells ectopically expressing an NLR gene product, and primary cells from humans with an autoinflammatory syndrome resulting from mutation of an NLR, MAS, to comprehensively define the immunologic functions of the NLR family member NLRC4. A specific function of NLRC4 is induction of the beta subunit of the interleukin-12 receptor (IL12RB2). </p> <p> </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14876928 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | NLRC4 regulates a unique immunologic program. Mamoor, Shahan <p>We have defined transcription control of the innate immune system by the NLR family member NOD2 and its pathologic counterpart in the inflammatory bowel disease Crohn's Disease, described NLRC4 as an inhibitor of the interferon signaling pathway, and demonstrated that the NLR family member NLRP10 regulates interactions between the adaptive and innate arms of the immune system (particularly at the B-cell immunologic synapse involving CD40 and the BAFF receptor) as well as discovering novel surveillance activities for an NLR protein, wherein NLRP10 functioned as a sensor of cell cycle speed. </p> <p>Here we utilized whole transcriptome technologies, human cells ectopically expressing an NLR gene product, and primary cells from humans with an autoinflammatory syndrome resulting from mutation of an NLR, MAS, to comprehensively define the immunologic functions of the NLR family member NLRC4. A specific function of NLRC4 is induction of the beta subunit of the interleukin-12 receptor (IL12RB2). </p> <p> </p> |
| title | NLRC4 regulates a unique immunologic program. |
| url | https://doi.org/10.5281/zenodo.14876928 |