The Pathophysiology and Role of IL-7 in the Immune Response and Autoimmune Diseases: A Review Article
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| Format: | Recurso digital |
| Language: | English, Old (ca. 450-1100) |
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Zenodo
2025
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| _version_ | 1866901708129435648 |
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| author | Bareq A. Al-lateef Zainab H. Al-Zubaidy Ali Dhaher Marhash Ali A. Al-fahham |
| author_facet | Bareq A. Al-lateef Zainab H. Al-Zubaidy Ali Dhaher Marhash Ali A. Al-fahham |
| contents | <p>IL-7 is one of the very important cytokines in the regulation and maintenance of immune responses. IL-7 has been described as a very pivotal lymphocyte development, homeostasis, and activation mediator. Recent studies focused on the pathways influenced by IL-7 and their role in innate and adaptive immunities. Interleukin-7 (IL-7) is a critical cytokine in the development and homeostasis of T cells, as well as the signaling of other immune cells, such as natural killer (NK) cells. IL-7 signaling is also important for the majority of T cell functions and disease associations, which include protection against infectious diseases, autoimmunity, and tumor malignancies. This paper reviews the current findings on IL-7 and its role in the immune response, with particular emphasis on the mechanisms of signaling pathways it induces and its effects on lymphocyte functions, therefore opening a window for a future therapeutic application. It also presents recent research findings on the role of IL-7 in the diseased state dynamics of many illnesses, which consequently underscores possible therapeutic applications while simultaneously pinpointing the shortcomings in the existing knowledge regarding the biology of IL-7.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14881053 |
| institution | Zenodo |
| language | ang |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | The Pathophysiology and Role of IL-7 in the Immune Response and Autoimmune Diseases: A Review Article Bareq A. Al-lateef Zainab H. Al-Zubaidy Ali Dhaher Marhash Ali A. Al-fahham ---------------------------- <p>IL-7 is one of the very important cytokines in the regulation and maintenance of immune responses. IL-7 has been described as a very pivotal lymphocyte development, homeostasis, and activation mediator. Recent studies focused on the pathways influenced by IL-7 and their role in innate and adaptive immunities. Interleukin-7 (IL-7) is a critical cytokine in the development and homeostasis of T cells, as well as the signaling of other immune cells, such as natural killer (NK) cells. IL-7 signaling is also important for the majority of T cell functions and disease associations, which include protection against infectious diseases, autoimmunity, and tumor malignancies. This paper reviews the current findings on IL-7 and its role in the immune response, with particular emphasis on the mechanisms of signaling pathways it induces and its effects on lymphocyte functions, therefore opening a window for a future therapeutic application. It also presents recent research findings on the role of IL-7 in the diseased state dynamics of many illnesses, which consequently underscores possible therapeutic applications while simultaneously pinpointing the shortcomings in the existing knowledge regarding the biology of IL-7.</p> |
| title | The Pathophysiology and Role of IL-7 in the Immune Response and Autoimmune Diseases: A Review Article |
| topic | ---------------------------- |
| url | https://doi.org/10.5281/zenodo.14881053 |