| _version_ | 1866901230205272064 |
|---|---|
| author | Sanika Chougule, Mayuri Choundikar*, Dhairyasheel Chavan, Vinayak Mane |
| author_facet | Sanika Chougule, Mayuri Choundikar*, Dhairyasheel Chavan, Vinayak Mane |
| contents | <p><span>Parasitic infections caused by helminths pose a significant public health and economic burden globally. The use of synthetic anthelmintic drugs, such as albendazole, is common; however, issues such as drug resistance and side effects necessitate the exploration of alternative treatments. This study investigates the anthelmintic properties of Duranta erecta leaf extract and compares its efficacy to albendazole.The study involved the preparation of methanolic<span> </span>of Duranta erecta leaves, which were tested on Eisenia Fetida (Indian earthworm) as a model organism. The anthelmintic activity was assessed based on the time taken for paralysis and death of the worms at (10mg/ML)concentration and compared with standard albendazole (10 mg/mL). Phytochemical screening revealed the presence of bioactive compounds, including alkaloids, flavonoids, and saponins, which may contribute to the extract's activity. Results showed that Duranta erecta extracts exhibited significant anthelmintic activity in a concentration-dependent manner, with the methanolic extract demonstrating higher efficacy . While albendazole remained more potent overall, the extracts displayed comparable activity at higher concentrations. This study highlights the potential of Duranta erecta as a natural anthelmintic agent and suggests further exploration into its bioactive compounds for the development of plant-based anthelmintic drugs.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14885691 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | In Vitro Anthalmentic Activity and Phytochemical Screening of Methanolic Extract of Duranta Erecta Leaves Sanika Chougule, Mayuri Choundikar*, Dhairyasheel Chavan, Vinayak Mane Anthelmentic activity, Duranta erecta, Albendazole, Methanolic extract. <p><span>Parasitic infections caused by helminths pose a significant public health and economic burden globally. The use of synthetic anthelmintic drugs, such as albendazole, is common; however, issues such as drug resistance and side effects necessitate the exploration of alternative treatments. This study investigates the anthelmintic properties of Duranta erecta leaf extract and compares its efficacy to albendazole.The study involved the preparation of methanolic<span> </span>of Duranta erecta leaves, which were tested on Eisenia Fetida (Indian earthworm) as a model organism. The anthelmintic activity was assessed based on the time taken for paralysis and death of the worms at (10mg/ML)concentration and compared with standard albendazole (10 mg/mL). Phytochemical screening revealed the presence of bioactive compounds, including alkaloids, flavonoids, and saponins, which may contribute to the extract's activity. Results showed that Duranta erecta extracts exhibited significant anthelmintic activity in a concentration-dependent manner, with the methanolic extract demonstrating higher efficacy . While albendazole remained more potent overall, the extracts displayed comparable activity at higher concentrations. This study highlights the potential of Duranta erecta as a natural anthelmintic agent and suggests further exploration into its bioactive compounds for the development of plant-based anthelmintic drugs.</span></p> |
| title | In Vitro Anthalmentic Activity and Phytochemical Screening of Methanolic Extract of Duranta Erecta Leaves |
| topic | Anthelmentic activity, Duranta erecta, Albendazole, Methanolic extract. |
| url | https://doi.org/10.5281/zenodo.14885691 |