Unusual negative selection pressure and lack of adaptation in SARS-CoV-2 ancestors
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| Format: | Recurso digital |
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Zenodo
2025
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| _version_ | 1866902267858255872 |
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| author | Jankovic, David |
| author_facet | Jankovic, David |
| contents | <p>Measures of the proportion of non-synonymous to synonymous mutations such as dN/dS are used to estimate selection forces acting on a genome, gene, or smaller region of that gene. Here a simple ratio of synonymous to non-synonymous mutations is applied to pairs of sequences ancestral to SARS-CoV-2 and also to non-SARS-CoV-2 related control groups. This analysis reveals between some pairs of close ancestors, and SARS-CoV-2, an unexpectedly high proportion of synonymous mutations, suggesting negative selection – even despite the switch in host species and tissue tropism. This suggests a need for further investigation.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14904448 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Unusual negative selection pressure and lack of adaptation in SARS-CoV-2 ancestors Jankovic, David <p>Measures of the proportion of non-synonymous to synonymous mutations such as dN/dS are used to estimate selection forces acting on a genome, gene, or smaller region of that gene. Here a simple ratio of synonymous to non-synonymous mutations is applied to pairs of sequences ancestral to SARS-CoV-2 and also to non-SARS-CoV-2 related control groups. This analysis reveals between some pairs of close ancestors, and SARS-CoV-2, an unexpectedly high proportion of synonymous mutations, suggesting negative selection – even despite the switch in host species and tissue tropism. This suggests a need for further investigation.</p> |
| title | Unusual negative selection pressure and lack of adaptation in SARS-CoV-2 ancestors |
| url | https://doi.org/10.5281/zenodo.14904448 |