FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF ITRACONOZOLE BY USING NATURAL AND SYNTHETIC POLYMERS
Fuente:
Zenodo
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Recurso digital |
| Language: | English |
| Published: |
Zenodo
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866902227522682880 |
|---|---|
| author | Munija Panchenddula Deverkonda Nikitha Afra Fathima M. Nithya Yashasvi Lakkakula Prashanthi* |
| author_facet | Munija Panchenddula Deverkonda Nikitha Afra Fathima M. Nithya Yashasvi Lakkakula Prashanthi* |
| contents | <p><span>Itraconazole is an antifungal medication used to treat a number of fungal infections and has half-life 21 h. Sustained release. The main objective of the present study was to develop sustained release formulation using Natural and synthetic polymers i.e., Sodium alginate, Chitosan and HPMC K 15 M respectively. Drug Excipient Compatibility studies revealed that there was no considerable change. Direct compression technique was used to prepare tablets which were evaluated for pre compression and post compression parameters. Nine formulations were prepared in which F1-F3 were prepared using Sodium alginate, F4-F6 by Chitosan and F7-F9 using HPMC K 15 M polymers at 1:1, 1:2 and 1:3 to the drug and polymer ratios respectively. F7 was selected as the best formulation which sustained the drug release up to 99.71 % in 12 h out of nine formulations (F1-F9). Release model of sample was found to follow zero order kinetics with high linearity. The best formulation was found to be stable during stability studies for 3 months.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14938906 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF ITRACONOZOLE BY USING NATURAL AND SYNTHETIC POLYMERS Munija Panchenddula Deverkonda Nikitha Afra Fathima M. Nithya Yashasvi Lakkakula Prashanthi* Chitosan compatibility direct compression Hpmc K 15 m Sodium alginate Sustained release <p><span>Itraconazole is an antifungal medication used to treat a number of fungal infections and has half-life 21 h. Sustained release. The main objective of the present study was to develop sustained release formulation using Natural and synthetic polymers i.e., Sodium alginate, Chitosan and HPMC K 15 M respectively. Drug Excipient Compatibility studies revealed that there was no considerable change. Direct compression technique was used to prepare tablets which were evaluated for pre compression and post compression parameters. Nine formulations were prepared in which F1-F3 were prepared using Sodium alginate, F4-F6 by Chitosan and F7-F9 using HPMC K 15 M polymers at 1:1, 1:2 and 1:3 to the drug and polymer ratios respectively. F7 was selected as the best formulation which sustained the drug release up to 99.71 % in 12 h out of nine formulations (F1-F9). Release model of sample was found to follow zero order kinetics with high linearity. The best formulation was found to be stable during stability studies for 3 months.</span></p> |
| title | FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF ITRACONOZOLE BY USING NATURAL AND SYNTHETIC POLYMERS |
| topic | Chitosan compatibility direct compression Hpmc K 15 m Sodium alginate Sustained release |
| url | https://doi.org/10.5281/zenodo.14938906 |