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2025
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| Online Access: | https://doi.org/10.5281/zenodo.14947211 |
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| _version_ | 1866901857103773696 |
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| author | Das, Viswanath |
| author_facet | Das, Viswanath |
| contents | <p>Source Data File 1 (Figure 1): Raw thioflavin T (ThT) fluorescence data of tau peptide aggregation is shown in Figure 1b.</p> <p>Source Data File 2 (Figure 2): Raw sensorgram data for titration curve kinetics of purpurin and oleocanthal binding with wildtype (WT) and mutant tau shown in Figure 2a, b.</p> <p>Source Data File 3 (Figure 3): Raw thioflavin T (ThT) fluorescence data of tau peptide aggregation in the absence (control) and presence of purpurin or oleocanthal shown in Figure 3a.</p> <p>Source Data File 4 (Figure 4): Number of nuclei and aggregates used for calculating the normalized aggregate number in HEK293T Tau-RD P301S FRET Biosensor cells shown in Fig. 4b.</p> <p>Source Data File S1 (Figure S1): Raw fluorescence measurement data of thioflavin T (ThT), purpurin, and oleocanthal shown in Supplementary Figure S1.</p> <p>Supplementary Dataset S1: MM-GBSA Binding Free Energy Calculations for Purpurin and Oleocanthal with WT and P301L Tau Filaments.</p> <p>Supplementary Dataset S2: Residue Decomposition Analysis of Purpurin and Oleocanthal Binding to WT and P301L Tau Filaments.</p> <p> </p> <p> </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14947211 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Structural and Functional Insights into the Selective Inhibition of Mutant Tau Aggregation by Purpurin and Oleocanthal in Frontotemporal Dementia Das, Viswanath <p>Source Data File 1 (Figure 1): Raw thioflavin T (ThT) fluorescence data of tau peptide aggregation is shown in Figure 1b.</p> <p>Source Data File 2 (Figure 2): Raw sensorgram data for titration curve kinetics of purpurin and oleocanthal binding with wildtype (WT) and mutant tau shown in Figure 2a, b.</p> <p>Source Data File 3 (Figure 3): Raw thioflavin T (ThT) fluorescence data of tau peptide aggregation in the absence (control) and presence of purpurin or oleocanthal shown in Figure 3a.</p> <p>Source Data File 4 (Figure 4): Number of nuclei and aggregates used for calculating the normalized aggregate number in HEK293T Tau-RD P301S FRET Biosensor cells shown in Fig. 4b.</p> <p>Source Data File S1 (Figure S1): Raw fluorescence measurement data of thioflavin T (ThT), purpurin, and oleocanthal shown in Supplementary Figure S1.</p> <p>Supplementary Dataset S1: MM-GBSA Binding Free Energy Calculations for Purpurin and Oleocanthal with WT and P301L Tau Filaments.</p> <p>Supplementary Dataset S2: Residue Decomposition Analysis of Purpurin and Oleocanthal Binding to WT and P301L Tau Filaments.</p> <p> </p> <p> </p> |
| title | Structural and Functional Insights into the Selective Inhibition of Mutant Tau Aggregation by Purpurin and Oleocanthal in Frontotemporal Dementia |
| url | https://doi.org/10.5281/zenodo.14947211 |