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Computational Design and Validation of a p53-SOG1 Hybrid Transcription Factor for Cancer Therapy and DNA Damage Response

Fuente: Zenodo
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Bibliographic Details
Main Author: Quazi, Uzaif
Format: Recurso digital
Language:English
Published: Zenodo 2025
Subjects:
p53-SOG1 hybrid protein
Hybrid transcription factor Synthetic transcription factors Cross-species DNA damage response
Cancer therapy using hybrid proteins
Tumor suppressor hybridization Computational protein design Molecular docking of transcription factors Molecular dynamics simulation of p53 DNA-binding efficiency in hybrid proteins Tetramerization of p53 hybrid Hybrid protein structural validation Synthetic biology and cancer therapeutics Bioinformatics in cancer drug development Protein engineering for tumor suppression In silico validation of transcription factors Functional validation of hybrid proteins
Novel synthetic transcription factors Enhanced DNA-binding in hybrid p53 GROMACS simulation of DNA-binding proteins Computational approach to cancer treatment Protein hybridization for therapeutic applications p53 tumor suppressor engineering Molecular docking analysis of p53 hybrid Computational biology in cancer research Hybrid transcription factors in synthetic biology Structural modeling of DNA-binding proteins p53 and SOG1 fusion protein Protein stability analysis in hybrid molecules
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