Therapeutic targeting in breast cancer for the treatment of lung metastasis: PPP1R9A.
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2025
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| _version_ | 1866902189061963776 |
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| author | Mamoor, Shahan |
| author_facet | Mamoor, Shahan |
| contents | <p>Metastasis is the major cause of death from cancer and metastasis to the lung in breast cancer is difficult to treat and heterogeneous in nature, complicating its management (1-5). We recently utilized whole transcriptome technologies to define the full complement of differentially expressed kinases and phosphatases in HER2+ breast cancer: in the primary tumor, and in metastasis to the CNS (6-8). Here we utilize whole transcriptome technologies (9, 10) to measure total transcription in the lung metastases of humans with breast cancer. We identify here a therapeutic target based on its differential expression and up-regulation upon metastasis to the lung in humans with breast cancer, PPP1R9A, as a candidate therapeutic target for the medical management of lung metastasis. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14977189 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Therapeutic targeting in breast cancer for the treatment of lung metastasis: PPP1R9A. Mamoor, Shahan <p>Metastasis is the major cause of death from cancer and metastasis to the lung in breast cancer is difficult to treat and heterogeneous in nature, complicating its management (1-5). We recently utilized whole transcriptome technologies to define the full complement of differentially expressed kinases and phosphatases in HER2+ breast cancer: in the primary tumor, and in metastasis to the CNS (6-8). Here we utilize whole transcriptome technologies (9, 10) to measure total transcription in the lung metastases of humans with breast cancer. We identify here a therapeutic target based on its differential expression and up-regulation upon metastasis to the lung in humans with breast cancer, PPP1R9A, as a candidate therapeutic target for the medical management of lung metastasis. </p> |
| title | Therapeutic targeting in breast cancer for the treatment of lung metastasis: PPP1R9A. |
| url | https://doi.org/10.5281/zenodo.14977189 |