Formulation and Evaluation of Nano-emulsion Based Hydrogel of Posaconazole for Enhanced Antifungal Activity
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2025
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| _version_ | 1866901245751459840 |
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| author | Dr. Amul Mishra, Mohammad Azhar |
| author_facet | Dr. Amul Mishra, Mohammad Azhar |
| contents | <p><span>Posaconazole (POS) is a widely utilized antifungal medication for the treatment of fungal infections. It falls under the triazole class of drugs. The bioavailability of Posaconazole experiences a significant decrease due to its low solubility in water (less than 1 g/ml) and substantial metabolism in the liver during the first pass. The development of effective pharmacological formulations poses a significant challenge, as instability or reduced solubility in the medium can greatly diminish pharmacological efficacy. Among the most advanced methods for improving the bioavailability and solubility of Posaconazole is the nano-emulgel drug delivery system. The aim of the study is to create a posaconazole-loaded nanoemulsion based gel for topical application, which will provide sustained release of the drug, enhance patient compliance, and eliminate the need for frequent administration.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_14995303 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Formulation and Evaluation of Nano-emulsion Based Hydrogel of Posaconazole for Enhanced Antifungal Activity Dr. Amul Mishra, Mohammad Azhar Nanoemulsion, Hydrogel, fungal infection, Posaconazole, Nanoparticle <p><span>Posaconazole (POS) is a widely utilized antifungal medication for the treatment of fungal infections. It falls under the triazole class of drugs. The bioavailability of Posaconazole experiences a significant decrease due to its low solubility in water (less than 1 g/ml) and substantial metabolism in the liver during the first pass. The development of effective pharmacological formulations poses a significant challenge, as instability or reduced solubility in the medium can greatly diminish pharmacological efficacy. Among the most advanced methods for improving the bioavailability and solubility of Posaconazole is the nano-emulgel drug delivery system. The aim of the study is to create a posaconazole-loaded nanoemulsion based gel for topical application, which will provide sustained release of the drug, enhance patient compliance, and eliminate the need for frequent administration.</span></p> |
| title | Formulation and Evaluation of Nano-emulsion Based Hydrogel of Posaconazole for Enhanced Antifungal Activity |
| topic | Nanoemulsion, Hydrogel, fungal infection, Posaconazole, Nanoparticle |
| url | https://doi.org/10.5281/zenodo.14995303 |