Neurodevelopmental outcome of new-borns with neonatal seizures at 6 and 12 months of age – a prospective cohort study at Children Hospital Bemina, GMC Srinagar, Jammu and Kashmir, India.
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| Language: | English |
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2025
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| _version_ | 1866901808896540672 |
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| author | Indian Journal of Developmental & Behavioral Pediatrics (Official Journal of IAP Chapter of Neurodevelopmental Pediatrics) |
| author_facet | Indian Journal of Developmental & Behavioral Pediatrics (Official Journal of IAP Chapter of Neurodevelopmental Pediatrics) |
| contents | <p>Abstract:<br>Introduction: Neonatal seizures represent the most prevalent neurological disorder in newborns <br>and are critical for neurodevelopmental outcomes [1]. These seizures frequently occur during <br>the neonatal period, with an incidence ranging from 1.5 to 5.5 per 1000 live births, and are <br>more prevalent in preterm infants due to brain immaturity and increased risk of injury [2,3]. <br>They signify neurological dysfunction, which may be reversible or persistent depending on <br>the underlying cause. Prompt diagnosis and intervention are imperative to reduce mortality and <br>mitigate long-term neurological consequences.Methods: This prospective cohort study was conducted on neonates admitted with seizures between January 2022 and March 2023 in the Neonatology Division, Department of <br>Pediatrics, GMC Srinagar. Following history taking, physical examination, and etiological screening, data were systematically recorded. Neonates were monitored in a high-risk neonatal outpatient department, conducted biweekly. The Amiel Tison neurological examination was performed at discharge and during follow-up. Neurodevelopmental assessment was conducted at 6 and 12 months using the Denver Developmental Screening Test II (DDST – II) <br>in collaboration with a clinical psychologist. Univariate analysis was employed to examine <br>the relationship between risk factors and neurodevelopmental outcomes. Categorical data <br>were compared using the Chi-square or Fisher’s exact test, with statistical significance set at p ≤ <br>0.05. Relative Risk (RR) with a 95% confidence interval (CI) was calculated.Results: During the study period, 367 neonates <br>were admitted to the NICU with seizures. After applying the selection criteria, 120 neonates <br>were included in the study. It was observed that 61.66% (n=74) exhibited normal development, </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15124689 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Neurodevelopmental outcome of new-borns with neonatal seizures at 6 and 12 months of age – a prospective cohort study at Children Hospital Bemina, GMC Srinagar, Jammu and Kashmir, India. Indian Journal of Developmental & Behavioral Pediatrics (Official Journal of IAP Chapter of Neurodevelopmental Pediatrics) Neurodevelopmental, new-borns, seizures <p>Abstract:<br>Introduction: Neonatal seizures represent the most prevalent neurological disorder in newborns <br>and are critical for neurodevelopmental outcomes [1]. These seizures frequently occur during <br>the neonatal period, with an incidence ranging from 1.5 to 5.5 per 1000 live births, and are <br>more prevalent in preterm infants due to brain immaturity and increased risk of injury [2,3]. <br>They signify neurological dysfunction, which may be reversible or persistent depending on <br>the underlying cause. Prompt diagnosis and intervention are imperative to reduce mortality and <br>mitigate long-term neurological consequences.Methods: This prospective cohort study was conducted on neonates admitted with seizures between January 2022 and March 2023 in the Neonatology Division, Department of <br>Pediatrics, GMC Srinagar. Following history taking, physical examination, and etiological screening, data were systematically recorded. Neonates were monitored in a high-risk neonatal outpatient department, conducted biweekly. The Amiel Tison neurological examination was performed at discharge and during follow-up. Neurodevelopmental assessment was conducted at 6 and 12 months using the Denver Developmental Screening Test II (DDST – II) <br>in collaboration with a clinical psychologist. Univariate analysis was employed to examine <br>the relationship between risk factors and neurodevelopmental outcomes. Categorical data <br>were compared using the Chi-square or Fisher’s exact test, with statistical significance set at p ≤ <br>0.05. Relative Risk (RR) with a 95% confidence interval (CI) was calculated.Results: During the study period, 367 neonates <br>were admitted to the NICU with seizures. After applying the selection criteria, 120 neonates <br>were included in the study. It was observed that 61.66% (n=74) exhibited normal development, </p> |
| title | Neurodevelopmental outcome of new-borns with neonatal seizures at 6 and 12 months of age – a prospective cohort study at Children Hospital Bemina, GMC Srinagar, Jammu and Kashmir, India. |
| topic | Neurodevelopmental, new-borns, seizures |
| url | https://doi.org/10.5281/zenodo.15124689 |