The Co-Evolutionary Birth of the Ribosome: A Matter World Hypothesis Perspective(Estimated Calculation)
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2025
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| author | Reza Hashemi |
| author_facet | Reza Hashemi |
| contents | <p>The Matter World Hypothesis (MWH) posits that life emerged from the co-evolution of diverse prebiotic molecules—RNA, peptides, lipids, and metal ions—under fluctuating environmental conditions. This study investigates the origin of the ribosome, a ~3.7-MDa RNA-protein complex central to protein synthesis, which challenges single-molecule origin theories like the RNA World. Using over 100,000 estimated stochastic simulation calculations, we demonstrate that proto-ribosomes likely formed through probabilistic RNA-peptide-metal ion interactions, guided by environmental selection. In simulated prebiotic settings (e.g., hydrothermal vents, wet-dry cycles), compartmentalized systems achieved a >50% success rate, compared to <1% for RNA-only systems. These findings affirm MWH’s premise that life’s molecular machinery arose from collective dynamics, offering a testable framework for origins research.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15156904 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | The Co-Evolutionary Birth of the Ribosome: A Matter World Hypothesis Perspective(Estimated Calculation) Reza Hashemi Ribosome origin, Matter World Hypothesis, stochastic simulations, prebiotic chemistry, co-evolution <p>The Matter World Hypothesis (MWH) posits that life emerged from the co-evolution of diverse prebiotic molecules—RNA, peptides, lipids, and metal ions—under fluctuating environmental conditions. This study investigates the origin of the ribosome, a ~3.7-MDa RNA-protein complex central to protein synthesis, which challenges single-molecule origin theories like the RNA World. Using over 100,000 estimated stochastic simulation calculations, we demonstrate that proto-ribosomes likely formed through probabilistic RNA-peptide-metal ion interactions, guided by environmental selection. In simulated prebiotic settings (e.g., hydrothermal vents, wet-dry cycles), compartmentalized systems achieved a >50% success rate, compared to <1% for RNA-only systems. These findings affirm MWH’s premise that life’s molecular machinery arose from collective dynamics, offering a testable framework for origins research.</p> |
| title | The Co-Evolutionary Birth of the Ribosome: A Matter World Hypothesis Perspective(Estimated Calculation) |
| topic | Ribosome origin, Matter World Hypothesis, stochastic simulations, prebiotic chemistry, co-evolution |
| url | https://doi.org/10.5281/zenodo.15156904 |