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2025
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| Online Access: | https://doi.org/10.5281/zenodo.15185106 |
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| author | Shantanu Bele, Shaunak Bele, Aarati Sawanji, Vaibhav Khadul*, Mayur Pawar, Akshay Khatal |
| author_facet | Shantanu Bele, Shaunak Bele, Aarati Sawanji, Vaibhav Khadul*, Mayur Pawar, Akshay Khatal |
| contents | <p><span>The mechanism of action (MOA) and effectiveness of vonoprazan, a potassium-competitive acid blocker (P-CAB), are very different from those of conventional proton pump inhibitors (PPIs) such as omeprazole and esomeprazole.Unlike PPIs, which require activation in an acidic environment and irreversibly inhibit the H⁺/K⁺-ATPase enzyme, Vonoprazan directly and reversibly blocks this enzyme without requiring prior activation. As<span> </span>a<span> </span>result,<span> </span>gastric<span> </span>acid<span> </span>secretion can be suppressed<span> </span>more<span> </span>rapidly ,<span> </span>potently , and<span> </span>sustainably . Studies have shown that Vonoprazan achieves higher gastric pH levels more quickly & maintains them for a longer duration compared to PPIs, making it particularly effective for patients with severe acid-related disorders. Additionally, it is more stable in acidic conditions, providing consistent efficacy even in cases where PPIs may be less effective, such as Helicobacter pylori eradication or refractory gastro-esophageal reflux disease (GERD)</span><span lang="EN-US">. </span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15185106 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Review on: Comparative study of Proton pump inhibitors & Vonoprazan with respect to Anti-ulcer activity Shantanu Bele, Shaunak Bele, Aarati Sawanji, Vaibhav Khadul*, Mayur Pawar, Akshay Khatal Vonoprazan, Proton pump inhibitors, Helicobacter pylori , Potassium-competitive acid blockers, gastro-esophageal reflux disease. <p><span>The mechanism of action (MOA) and effectiveness of vonoprazan, a potassium-competitive acid blocker (P-CAB), are very different from those of conventional proton pump inhibitors (PPIs) such as omeprazole and esomeprazole.Unlike PPIs, which require activation in an acidic environment and irreversibly inhibit the H⁺/K⁺-ATPase enzyme, Vonoprazan directly and reversibly blocks this enzyme without requiring prior activation. As<span> </span>a<span> </span>result,<span> </span>gastric<span> </span>acid<span> </span>secretion can be suppressed<span> </span>more<span> </span>rapidly ,<span> </span>potently , and<span> </span>sustainably . Studies have shown that Vonoprazan achieves higher gastric pH levels more quickly & maintains them for a longer duration compared to PPIs, making it particularly effective for patients with severe acid-related disorders. Additionally, it is more stable in acidic conditions, providing consistent efficacy even in cases where PPIs may be less effective, such as Helicobacter pylori eradication or refractory gastro-esophageal reflux disease (GERD)</span><span lang="EN-US">. </span></p> |
| title | Review on: Comparative study of Proton pump inhibitors & Vonoprazan with respect to Anti-ulcer activity |
| topic | Vonoprazan, Proton pump inhibitors, Helicobacter pylori , Potassium-competitive acid blockers, gastro-esophageal reflux disease. |
| url | https://doi.org/10.5281/zenodo.15185106 |