Analytical and Pharmaceutical Consideration of the Anticoagulant Drug Apixaban: A Comprehensive Review
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2025
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| author | Devayan Vyas*, Amit Sapara, Nikunj Dave, Kartik Vyas, Kiran Nimavat |
| author_facet | Devayan Vyas*, Amit Sapara, Nikunj Dave, Kartik Vyas, Kiran Nimavat |
| contents | <p><span lang="EN-US">Apixaban, a widely used direct oral anticoagulant (DOAC), is pivotal for managing thromboembolic conditions. This study reviews advancements in analytical methodologies, including high-performance liquid chromatography (HPLC) and UV spectrophotometric techniques, utilized for their quantification in various matrices. Pharmaceutical developments, such as formulation strategies, bioavailability improvements, and stability enhancements, have also been explored. Additionally, this study assessed the pharmacokinetic and pharmacodynamic properties of apixaban, along with its clinical implications and safety profile. A comprehensive literature review covering 2015-2024 has been conducted to ensure that the review is current and inclusive, highlighting recent advancements and innovative approaches in the development of analytical methods. These findings underscore the critical need for ongoing research to enhance analytical methodologies and optimize pharmaceutical formulations, aiming to achieve improved therapeutic outcomes for patients treated with apixaban. Future research directions are suggested to address the challenges associated with the long-term use of apixaban and to explore novel applications in various clinical settings</span><span lang="EN-US">. </span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15185692 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Analytical and Pharmaceutical Consideration of the Anticoagulant Drug Apixaban: A Comprehensive Review Devayan Vyas*, Amit Sapara, Nikunj Dave, Kartik Vyas, Kiran Nimavat Apixaban, Anticoagulant, UV spectrophotometry, HPLC, Method development, Validation. <p><span lang="EN-US">Apixaban, a widely used direct oral anticoagulant (DOAC), is pivotal for managing thromboembolic conditions. This study reviews advancements in analytical methodologies, including high-performance liquid chromatography (HPLC) and UV spectrophotometric techniques, utilized for their quantification in various matrices. Pharmaceutical developments, such as formulation strategies, bioavailability improvements, and stability enhancements, have also been explored. Additionally, this study assessed the pharmacokinetic and pharmacodynamic properties of apixaban, along with its clinical implications and safety profile. A comprehensive literature review covering 2015-2024 has been conducted to ensure that the review is current and inclusive, highlighting recent advancements and innovative approaches in the development of analytical methods. These findings underscore the critical need for ongoing research to enhance analytical methodologies and optimize pharmaceutical formulations, aiming to achieve improved therapeutic outcomes for patients treated with apixaban. Future research directions are suggested to address the challenges associated with the long-term use of apixaban and to explore novel applications in various clinical settings</span><span lang="EN-US">. </span></p> |
| title | Analytical and Pharmaceutical Consideration of the Anticoagulant Drug Apixaban: A Comprehensive Review |
| topic | Apixaban, Anticoagulant, UV spectrophotometry, HPLC, Method development, Validation. |
| url | https://doi.org/10.5281/zenodo.15185692 |