Homeostasis-driven growth and remodelling affects the biomechanical assessment of atherosclerotic carotid vessels
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2025
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| _version_ | 1866901614150811648 |
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| author | Mastrofini, Alessandro Karlof, Eva Hedin, Ulf Gasser, Thomas Christian Marino, Michele |
| author_facet | Mastrofini, Alessandro Karlof, Eva Hedin, Ulf Gasser, Thomas Christian Marino, Michele |
| contents | <div> <div>The role of homeostasis-driven growth and remodeling (G&R) in vascular adaptation to pathological biomechanical environments remains largely unexplored. This study extends our previous work by refining a computational workflow that integrates homeostasis-driven G&R into patient-specific carotid geometries. Key advancements include adopting a total Lagrangian framework to handle complex geometries, introducing novel post-processing metrics for improved comparisons, and conducting statistical analyses to assess G&R’s impact on biomechanical evaluations of atherosclerotic vessels. These improvements enabled the analysis of a cohort of 18 cases, incorporating patient-specific geometries and pathological tissue distributions reconstructed from clinical imaging data. Results suggest that G&R generally reduces peak stress, though its effectiveness depends on plaque morphology and tissue composition. High calcification leads to localized stress concentrations, limiting remodeling, whereas matrix-rich regions promote stress homogenization. At the cohort level, findings underscore the need for patient-specific analyses in plaque risk evaluation, reinforcing the importance of personalized biomechanical modeling in assessing atherosclerotic disease and guiding clinical decision-making.</div> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15210496 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Homeostasis-driven growth and remodelling affects the biomechanical assessment of atherosclerotic carotid vessels Mastrofini, Alessandro Karlof, Eva Hedin, Ulf Gasser, Thomas Christian Marino, Michele Atherosclerosis Tissue stress growth and remodeling computational biomechanics <div> <div>The role of homeostasis-driven growth and remodeling (G&R) in vascular adaptation to pathological biomechanical environments remains largely unexplored. This study extends our previous work by refining a computational workflow that integrates homeostasis-driven G&R into patient-specific carotid geometries. Key advancements include adopting a total Lagrangian framework to handle complex geometries, introducing novel post-processing metrics for improved comparisons, and conducting statistical analyses to assess G&R’s impact on biomechanical evaluations of atherosclerotic vessels. These improvements enabled the analysis of a cohort of 18 cases, incorporating patient-specific geometries and pathological tissue distributions reconstructed from clinical imaging data. Results suggest that G&R generally reduces peak stress, though its effectiveness depends on plaque morphology and tissue composition. High calcification leads to localized stress concentrations, limiting remodeling, whereas matrix-rich regions promote stress homogenization. At the cohort level, findings underscore the need for patient-specific analyses in plaque risk evaluation, reinforcing the importance of personalized biomechanical modeling in assessing atherosclerotic disease and guiding clinical decision-making.</div> </div> |
| title | Homeostasis-driven growth and remodelling affects the biomechanical assessment of atherosclerotic carotid vessels |
| topic | Atherosclerosis Tissue stress growth and remodeling computational biomechanics |
| url | https://doi.org/10.5281/zenodo.15210496 |