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| Formato: | Recurso digital |
| Lenguaje: | inglés |
| Publicado: |
Zenodo
2025
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| Materias: | |
| Acceso en línea: | https://doi.org/10.5281/zenodo.15233946 |
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- <p><strong><span lang="EN-US">Abstract</span></strong></p> <p><strong><span lang="EN-US">Introduction</span></strong><span lang="EN-US">: Testicular feminization is a syndrome in which a male, genetically XY with negative sex chromatin, is resistant to androgen hormones due to various abnormalities of the X chromosome. This resistance to androgen hormones prevents the formation of male genitalia and results in a female phenotype. Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) is the most common cause of vaginal absence, followed by complete or partial androgen insensitivity syndrome. Treatment for these patients varies from simple non-operative dilation to the more complicated surgical creation of a neovagina. In this context, we present a series of 5 cases with testicular feminization syndrome who were raised as females and underwent Bilateral Inguinal Orchidectomy and McIndoe’s Vaginoplasty with Bilateral Pudendal Artery Perforator Flap surgery, the outcome and quality of life.</span></p> <p><strong><span lang="EN-US">Methods</span></strong><span lang="EN-US">: A total of 5 cases of primary amenorrhea which also included two sisters were found to have testicular feminization syndrome (46 XY). Routine investigations were done. All 5 cases underwent bilateral inguinal orchidectomy and McIndoe's vaginoplasty with bilateral pudendal artery perforator flap surgery. Their neovagina width, length, granulation tissue, and stenosis were examined and recorded at follow-up visits. The primary outcomes were the achievement of anatomical and functional success.</span></p> <p><strong><span lang="EN-US">Results</span></strong><span lang="EN-US">: The effectiveness of the surgery was assessed by monitoring anatomical and functional outcomes. Donor site healing was adequate. An average vaginal length of 7-8 cm and vaginal width of about 3 cm was achieved. Sexual gratification was satisfactory. There was no blood transfusion requirement. Major complications were rare, except for local site pain or irritation.</span></p> <p><strong><span lang="EN-US">Conclusions</span></strong><span lang="EN-US">: Vaginal reconstruction with McIndoe technique with Bilateral Orchidectomy in Testicular Feminisation syndrome if performed with good surgical skills, is a secure and beneficial way to achieve sexual contentment, with no donor site complications</span></p>