Interstitial Lung Disease Associated with Chronic Nitrofurantoin Use

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Auteurs principaux: Erick Jafet González Roblero, Karla Fabiola Aguirre avila, Erika Patricia Cerna Alcantar, Elizabeth Arellano Pacheco, Diana Karen Fernández López, Hannia Sarali Mares Cárdenas, Roberto Teutli Pérez, Jesús Arturo Portillo Ibarra, Mirtha Saavedra Vazquez
Format: Recurso digital
Langue:anglo-saxon (environ 450-1100), ancien anglais
Publié: Zenodo 2025
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author Erick Jafet González Roblero
Karla Fabiola Aguirre avila
Erika Patricia Cerna Alcantar
Elizabeth Arellano Pacheco
Diana Karen Fernández López
Hannia Sarali Mares Cárdenas
Roberto Teutli Pérez
Jesús Arturo Portillo Ibarra
Mirtha Saavedra Vazquez
author_facet Erick Jafet González Roblero
Karla Fabiola Aguirre avila
Erika Patricia Cerna Alcantar
Elizabeth Arellano Pacheco
Diana Karen Fernández López
Hannia Sarali Mares Cárdenas
Roberto Teutli Pérez
Jesús Arturo Portillo Ibarra
Mirtha Saavedra Vazquez
contents <p><strong>Introduction: </strong>Since 2011, nitrofurantoin has been reconsidered as a first-line treatment, but it can cause rare pulmonary and liver toxicity. Chronic use can lead to interstitial lung disease (ILD). The case presented highlights the suspicion of ILD in patients with respiratory symptoms after prolonged nitrofurantoin use.</p> <p><strong>Case presentation: </strong>A 64-year-old woman receiving nitrofurantoin long-term developed severe pulmonary symptoms. After ruling out infections and autoimmune diseases, pulmonary toxicity was suspected. Treatment produced significant improvement, and she was discharged, continuing therapy and discontinuing nitrofurantoin.</p> <p><strong>Conclusion: </strong>Nitrofurantoin toxicity is underreported in Mexico. Despite being safe, prolonged use can cause serious effects, so regular follow-up is essential.</p>
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publishDate 2025
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spellingShingle Interstitial Lung Disease Associated with Chronic Nitrofurantoin Use
Erick Jafet González Roblero
Karla Fabiola Aguirre avila
Erika Patricia Cerna Alcantar
Elizabeth Arellano Pacheco
Diana Karen Fernández López
Hannia Sarali Mares Cárdenas
Roberto Teutli Pérez
Jesús Arturo Portillo Ibarra
Mirtha Saavedra Vazquez
Nitrofurantoin, Interstitial lung disease, Pulmonary fibrosis, Urinary tract infections, Adverse reaction to medications.
<p><strong>Introduction: </strong>Since 2011, nitrofurantoin has been reconsidered as a first-line treatment, but it can cause rare pulmonary and liver toxicity. Chronic use can lead to interstitial lung disease (ILD). The case presented highlights the suspicion of ILD in patients with respiratory symptoms after prolonged nitrofurantoin use.</p> <p><strong>Case presentation: </strong>A 64-year-old woman receiving nitrofurantoin long-term developed severe pulmonary symptoms. After ruling out infections and autoimmune diseases, pulmonary toxicity was suspected. Treatment produced significant improvement, and she was discharged, continuing therapy and discontinuing nitrofurantoin.</p> <p><strong>Conclusion: </strong>Nitrofurantoin toxicity is underreported in Mexico. Despite being safe, prolonged use can cause serious effects, so regular follow-up is essential.</p>
title Interstitial Lung Disease Associated with Chronic Nitrofurantoin Use
topic Nitrofurantoin, Interstitial lung disease, Pulmonary fibrosis, Urinary tract infections, Adverse reaction to medications.
url https://doi.org/10.5281/zenodo.15401215