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2025
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| Online Access: | https://doi.org/10.5281/zenodo.15427392 |
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| _version_ | 1866901595252326400 |
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| author | Narang, Benjamin |
| author_facet | Narang, Benjamin |
| contents | <p>Dataset used to explore the effects of intermittent exogenous ketosis on baroreflex sensitivity, ventilation, and heart rate variability at terrestrial high altitude.</p> <p>Participants completed baseline tests at sea level (SL) without any supplementation, followed by measurements in hypobaric hypoxia (HH), at a terrestrial altitude of 3375 m above sea level. For HH, participants either intermittently ingested exogenous ketones (IEK) or placebo (PLA) for the preceding two days of acclimatisation, prior to measurements on day 3 of the exposure.</p> <p>At both SL and at HH, participants were exposed to neutral (normoxic normocapnic), hypoxic (normocapnic) and hypercapnic (normoxic) conditions. Exposures lasted 6 minutes, during which time blood pressure, heart rate, pulse oxygen saturation and pulmonary ventilation were continuously measured. In the final 30 s of each stage, a capillary blood sample was obtained from the earlobe, for analysis of partial pressures of oxygen and carbon dioxide, pH, bicarbonate, and p50.</p> <p>Baroreflex sensitivity (BRS) was quantified using the sequence method, the hypoxic and hypercapnic ventilatory responses were quantified as the difference in ventilation relative to neutral conditions, expressed relative to the difference in pulse oxygen saturation (SpO2) and end-tidal carbon dioxide partial pressure (PetCO2), respectively. Heart rate variability was quantified under ambient conditions in each location only (SL neutral and HH hypoxia), using RMSSD, pNN50, low frequency power (LF), high frequency power (HF), and the LF/HF ratio.</p> <p>In the attached file, Sheet1 contains all data specific to each of the three conditions (neutral, hypoxia, hypercapnia) in each location (SL, HH). Sheet2 contains the data for which there was only one value per location (hypoxic ventilatory response, hypercapnic ventilatory response, heart rate variability metrics).</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15427392 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | IEK_Altitude_Baroreflex Narang, Benjamin <p>Dataset used to explore the effects of intermittent exogenous ketosis on baroreflex sensitivity, ventilation, and heart rate variability at terrestrial high altitude.</p> <p>Participants completed baseline tests at sea level (SL) without any supplementation, followed by measurements in hypobaric hypoxia (HH), at a terrestrial altitude of 3375 m above sea level. For HH, participants either intermittently ingested exogenous ketones (IEK) or placebo (PLA) for the preceding two days of acclimatisation, prior to measurements on day 3 of the exposure.</p> <p>At both SL and at HH, participants were exposed to neutral (normoxic normocapnic), hypoxic (normocapnic) and hypercapnic (normoxic) conditions. Exposures lasted 6 minutes, during which time blood pressure, heart rate, pulse oxygen saturation and pulmonary ventilation were continuously measured. In the final 30 s of each stage, a capillary blood sample was obtained from the earlobe, for analysis of partial pressures of oxygen and carbon dioxide, pH, bicarbonate, and p50.</p> <p>Baroreflex sensitivity (BRS) was quantified using the sequence method, the hypoxic and hypercapnic ventilatory responses were quantified as the difference in ventilation relative to neutral conditions, expressed relative to the difference in pulse oxygen saturation (SpO2) and end-tidal carbon dioxide partial pressure (PetCO2), respectively. Heart rate variability was quantified under ambient conditions in each location only (SL neutral and HH hypoxia), using RMSSD, pNN50, low frequency power (LF), high frequency power (HF), and the LF/HF ratio.</p> <p>In the attached file, Sheet1 contains all data specific to each of the three conditions (neutral, hypoxia, hypercapnia) in each location (SL, HH). Sheet2 contains the data for which there was only one value per location (hypoxic ventilatory response, hypercapnic ventilatory response, heart rate variability metrics).</p> |
| title | IEK_Altitude_Baroreflex |
| url | https://doi.org/10.5281/zenodo.15427392 |