ASSESSMENT OF VITAMIN C'S INFLUENCE ON SERUM LIPID PROFILES IN MALE ALBINO WISTAR RATS SUBJECTED TO NITROCELLULOSE THINNER: A COMPARATIVE STUDY OF INHALATION AND WHOLE-BODY EXPOSURE
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2025
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| author | Chibuzo Maduka UZOHO ONOHARIGHO Gift Kevwe |
| author_facet | Chibuzo Maduka UZOHO ONOHARIGHO Gift Kevwe |
| contents | <p>Occupational exposure to organic solvents like nitrocellulose thinner poses significant health risks, particularly in disrupting lipid metabolism. This study aimed to assess the impact of inhalation and whole-body exposure to nitrocellulose thinner on serum lipid profiles in male Albino Wistar rats and evaluate the potential protective effects of vitamin C supplementation. Thirty (30) rats were randomly assigned into five groups: control, inhalation exposure, whole-body exposure, inhalation + vitamin C, and whole-body exposure + vitamin C. Lipid parameters, including total cholesterol (TC), triglycerides (TG), high- density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were analyzed after 28 days of exposure. Results showed that both exposure routes significantly elevated TC, TG, and LDL-C compared to the control (p < 0.05), while reducing HDL-C, with whole-body exposure inducing more severe dyslipidemia. Vitamin C supplementation partially reversed these alterations, with greater efficacy in the inhalation group compared to whole-body exposure. This suggests that dermal absorption leads to more prolonged toxic effects than inhalation. These findings highlight the cardiovascular risks of solvent exposure and suggest antioxidant therapy as a potential intervention. Further research is needed to explore dose-dependent effects of vitamin C and long-term metabolic consequences of solvent exposure. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15471146 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | ASSESSMENT OF VITAMIN C'S INFLUENCE ON SERUM LIPID PROFILES IN MALE ALBINO WISTAR RATS SUBJECTED TO NITROCELLULOSE THINNER: A COMPARATIVE STUDY OF INHALATION AND WHOLE-BODY EXPOSURE Chibuzo Maduka UZOHO ONOHARIGHO Gift Kevwe <p>Occupational exposure to organic solvents like nitrocellulose thinner poses significant health risks, particularly in disrupting lipid metabolism. This study aimed to assess the impact of inhalation and whole-body exposure to nitrocellulose thinner on serum lipid profiles in male Albino Wistar rats and evaluate the potential protective effects of vitamin C supplementation. Thirty (30) rats were randomly assigned into five groups: control, inhalation exposure, whole-body exposure, inhalation + vitamin C, and whole-body exposure + vitamin C. Lipid parameters, including total cholesterol (TC), triglycerides (TG), high- density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were analyzed after 28 days of exposure. Results showed that both exposure routes significantly elevated TC, TG, and LDL-C compared to the control (p < 0.05), while reducing HDL-C, with whole-body exposure inducing more severe dyslipidemia. Vitamin C supplementation partially reversed these alterations, with greater efficacy in the inhalation group compared to whole-body exposure. This suggests that dermal absorption leads to more prolonged toxic effects than inhalation. These findings highlight the cardiovascular risks of solvent exposure and suggest antioxidant therapy as a potential intervention. Further research is needed to explore dose-dependent effects of vitamin C and long-term metabolic consequences of solvent exposure. </p> |
| title | ASSESSMENT OF VITAMIN C'S INFLUENCE ON SERUM LIPID PROFILES IN MALE ALBINO WISTAR RATS SUBJECTED TO NITROCELLULOSE THINNER: A COMPARATIVE STUDY OF INHALATION AND WHOLE-BODY EXPOSURE |
| url | https://doi.org/10.5281/zenodo.15471146 |