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2025
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| Online Access: | https://doi.org/10.5281/zenodo.15592999 |
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| author | Camilo Fernández Bravo, MD/PhD |
| author_facet | Camilo Fernández Bravo, MD/PhD |
| contents | <p>Abstract:</p> <p>Left ventricular assist devices (LVADs) are increasingly vital in the management of advanced heart failure. Despite their life-saving potential, perioperative complications, particularly stroke, remain a significant concern. This retrospective cohort study aimed to determine the incidence, identify independent risk factors, and evaluate the clinical outcomes of perioperative stroke following LVAD implantation at a major Brazilian referral center. Data from 250 consecutive patients undergoing LVAD implantation between January 2010 and December 2022 were analyzed. Perioperative stroke was defined as a new neurological deficit confirmed by imaging within 30 days of implantation or during the index hospitalization. Our findings reveal a perioperative stroke incidence of 7.6% (19 out of 250 patients). Multivariable logistic regression identified history of prior stroke/TIA, older age, prolonged cardiopulmonary bypass time, and low preoperative albumin as independent predictors of perioperative stroke. Patients experiencing perioperative stroke demonstrated significantly higher in-hospital mortality (36.8% vs. 8.7%, p <</p> <p>0.001), longer intensive care unit (ICU) and hospital stays (18 vs. 10 days, p < 0.001), and poorer functional recovery at discharge. These findings underscore the critical need for meticulous patient selection, aggressive risk stratification, and implementation of targeted preventative strategies to mitigate this devastating complication and improve post-LVAD outcomes. Keywords: Left Ventricular Assist Device, LVAD, Perioperative Stroke, Cerebrovascular Accident, Risk Factors, Outcomes, Heart Failure, Mechanical Circulatory Support, Brazil</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15592999 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Perioperative Stroke Following Left Ventricular Assist Device Implantation: Incidence, Risk Factors, and Clinical Outcomes – A Retrospective Cohort Study from a Brazilian Referral Center Camilo Fernández Bravo, MD/PhD <p>Abstract:</p> <p>Left ventricular assist devices (LVADs) are increasingly vital in the management of advanced heart failure. Despite their life-saving potential, perioperative complications, particularly stroke, remain a significant concern. This retrospective cohort study aimed to determine the incidence, identify independent risk factors, and evaluate the clinical outcomes of perioperative stroke following LVAD implantation at a major Brazilian referral center. Data from 250 consecutive patients undergoing LVAD implantation between January 2010 and December 2022 were analyzed. Perioperative stroke was defined as a new neurological deficit confirmed by imaging within 30 days of implantation or during the index hospitalization. Our findings reveal a perioperative stroke incidence of 7.6% (19 out of 250 patients). Multivariable logistic regression identified history of prior stroke/TIA, older age, prolonged cardiopulmonary bypass time, and low preoperative albumin as independent predictors of perioperative stroke. Patients experiencing perioperative stroke demonstrated significantly higher in-hospital mortality (36.8% vs. 8.7%, p <</p> <p>0.001), longer intensive care unit (ICU) and hospital stays (18 vs. 10 days, p < 0.001), and poorer functional recovery at discharge. These findings underscore the critical need for meticulous patient selection, aggressive risk stratification, and implementation of targeted preventative strategies to mitigate this devastating complication and improve post-LVAD outcomes. Keywords: Left Ventricular Assist Device, LVAD, Perioperative Stroke, Cerebrovascular Accident, Risk Factors, Outcomes, Heart Failure, Mechanical Circulatory Support, Brazil</p> |
| title | Perioperative Stroke Following Left Ventricular Assist Device Implantation: Incidence, Risk Factors, and Clinical Outcomes – A Retrospective Cohort Study from a Brazilian Referral Center |
| url | https://doi.org/10.5281/zenodo.15592999 |