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| Formato: | Recurso digital |
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Zenodo
2025
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| Acceso en línea: | https://doi.org/10.5281/zenodo.15594827 |
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- <p><span>In the current investigation, multicomponent reactions (MCRs) were used to condense a variety of substituted aromatic and heteroaromatic aldehydes with hydroxylamine hydrochloride, and ethyl acetoacetate to provide 3-methyl-4-(hetero)aryl methylene isoxazole-5(4<span>H</span>)-ones derivatives. Under ultrawave sonication, a Tulsion®-8052 MP resin accelerated the process at 45°C. The method outlined has the advantages of being safe, environmentally friendly, and economical because it produces isoxazole derivatives with a yield of 90-96% while removing the need for dangerous solvents.</span></p>