Hemophagocytic Subtype of Intravascular Large B-cell Lymphoma: An Unusual Finding
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| Natura: | Recurso digital |
| Lingua: | inglese |
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Zenodo
2025
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| _version_ | 1866902150894845952 |
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| author | Hanae Ben Abdenbi1,2*, Abderrahim El Ktaibi1,2 |
| author_facet | Hanae Ben Abdenbi1,2*, Abderrahim El Ktaibi1,2 |
| contents | <p><span lang="EN-US">Intravascular lymphoma (IVL) is an aggressive and rare disease with a poor prognosis classified by the World Health Organization (WHO) as a subtype of diffuse large B-cell lymphoma </span><span lang="EN-US">(DLBCL)</span><span lang="EN-US">. It is characterized by a proliferation of large neoplastic B cells within the lumina of small blood vessels, with minimal or no infiltration of the surrounding </span><span lang="EN-US">extravascular</span><span lang="EN-US"> tissue. </span><span lang="EN-US">The hemophagocytic subtype typically occurs in adults, with a median age of around 70 years and with no sex predilection. Herein, we present a case with hemophagocytic syndrome, including splenomegaly, fever, cytopenia (anemia and thrombocytopenia), </span><span lang="EN-US">macrophage activation syndrome and lymphocytosis observed on peripheral blood smear, which developed for seven weeks in a 75-year-old lady. Histological study</span><span lang="FR"> and immunohistochemical staining </span><span lang="EN-US">of the bone marrow biopsy revealed a proliferation of atypical lymphomatous cells within the lumen of <span>small</span></span><span lang="EN-US"> </span><span lang="EN-US">blood vessels.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15624991 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Hemophagocytic Subtype of Intravascular Large B-cell Lymphoma: An Unusual Finding Hanae Ben Abdenbi1,2*, Abderrahim El Ktaibi1,2 <p><span lang="EN-US">Intravascular lymphoma (IVL) is an aggressive and rare disease with a poor prognosis classified by the World Health Organization (WHO) as a subtype of diffuse large B-cell lymphoma </span><span lang="EN-US">(DLBCL)</span><span lang="EN-US">. It is characterized by a proliferation of large neoplastic B cells within the lumina of small blood vessels, with minimal or no infiltration of the surrounding </span><span lang="EN-US">extravascular</span><span lang="EN-US"> tissue. </span><span lang="EN-US">The hemophagocytic subtype typically occurs in adults, with a median age of around 70 years and with no sex predilection. Herein, we present a case with hemophagocytic syndrome, including splenomegaly, fever, cytopenia (anemia and thrombocytopenia), </span><span lang="EN-US">macrophage activation syndrome and lymphocytosis observed on peripheral blood smear, which developed for seven weeks in a 75-year-old lady. Histological study</span><span lang="FR"> and immunohistochemical staining </span><span lang="EN-US">of the bone marrow biopsy revealed a proliferation of atypical lymphomatous cells within the lumen of <span>small</span></span><span lang="EN-US"> </span><span lang="EN-US">blood vessels.</span></p> |
| title | Hemophagocytic Subtype of Intravascular Large B-cell Lymphoma: An Unusual Finding |
| url | https://doi.org/10.5281/zenodo.15624991 |